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Tbio
NRL
Neural retina-specific leucine zipper protein

Protein Summary
Description
Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001). This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396995
  • ENSP00000380191
  • ENSG00000129535
  • ENST00000396997
  • ENSP00000380193
  • ENST00000397002
  • ENSP00000380197
  • ENST00000560550
  • ENSP00000452966
  • ENST00000561028
  • ENSP00000454062
  • ENST00000642485
  • ENSP00000494928
  • ENSG00000285493
  • ENST00000643394
  • ENSP00000495627
  • ENST00000645740
  • ENSP00000495155
  • ENST00000646526
  • ENSP00000496316
  • ENST00000647376
  • ENSP00000496275

Symbol
  • D14S46E
  • RP27
  • D14S46E
  • NRL-MAF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
molecular function
0.86
protein domain
0.85
tissue sample
0.69
biological process
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 515.8   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 515.8   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
80.8
self reported educational attainment
1
1
1
80.8
liver fat measurement
1
1
1
61.4
liver disease biomarker
1
1
1
61.4
liver disease biomarker
1
1
1
61.4
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
80.8
self reported educational attainment
1
80.8
liver fat measurement
1
61.4
liver disease biomarker
1
61.4
liver disease biomarker
1
61.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neural retina leucine zipper
VGNC:3343
452806
Macaque
neural retina leucine zipper
714967
Mouse
MGI:102567
18185
Rat
RGD:1305197
290221
Dog
neural retina leucine zipper
VGNC:43972
490620
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neural retina leucine zipper
Macaque
neural retina leucine zipper
Mouse
Rat
Dog
neural retina leucine zipper
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P54845-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (20)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (96)
1 – 10 of 96
CRX
Tbio
Family: TF
Novelty: 0.00278097
Score: 0.965
Data Source: STRINGDB
NR2E3
Tbio
Family: NR
Novelty: 0.00643343
Score: 0.94
Data Source: STRINGDB
FIZ1
Tdark
Family: TF
Novelty: 0.30861253
Score: 0.868
Data Source: STRINGDB
RHO
Tbio
Family: GPCR
Novelty: 0.00012925
Score: 0.817
Data Source: STRINGDB
ROM1
Tbio
Novelty: 0.0088008
Score: 0.771
Data Source: STRINGDB
RORB
Tchem
Family: NR
Novelty: 0.0097843
Score: 0.737
Data Source: STRINGDB
RCVRN
Tbio
Novelty: 0.00266222
Score: 0.686
Data Source: STRINGDB
OTX2
Tbio
Family: TF
Novelty: 0.0024536
Score: 0.685
Data Source: STRINGDB
PDE6A
Tclin
Family: Enzyme
Novelty: 0.02680494
Score: 0.68
Data Source: STRINGDB
GNAT2
Tbio
Novelty: 0.01683655
Score: 0.675
Data Source: STRINGDB
Publication Statistics
PubMed Score  515.80

PubMed score by year
PubTator Score  131.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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