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Tbio
ATN1
Atrophin-1

Protein Summary
Description
Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-35 copies to 49-93 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356654
  • ENSP00000349076
  • ENSG00000111676
  • ENST00000396684
  • ENSP00000379915

Symbol
  • D12S755E
  • DRPLA
  • B37
  • HRS
  • NOD
  • DRPLA
  • D12S755E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.86
hub protein
0.85
transcription factor binding site profile
0.76
cell line
0.72
kinase
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.51   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.51   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Intracellular signaling by second messengers (R-HSA-9006925)

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular signaling by second messengers
Reactome
PIP3 activates AKT signaling
Reactome
PTEN Regulation
Reactome
Regulation of PTEN gene transcription
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Intracellular signaling by second messengers
PIP3 activates AKT signaling
PTEN Regulation
Regulation of PTEN gene transcription
Signal Transduction
Protein-Protein Interactions (143)
1 – 10 of 143
WDR5
Tchem
Novelty: 0.00689807
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.273
Data Source: BioPlex,STRINGDB
NR2E1
Tbio
Family: NR
Novelty: 0.02124787
Score: 0.98
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00013623
Score: 0.951
Data Source: STRINGDB
KDM1A
Tchem
Family: Epigenetic
Novelty: 0.00170368
Score: 0.946
Data Source: STRINGDB
HDAC3
Tclin
Family: Epigenetic
Novelty: 0.00453537
Score: 0.937
Data Source: STRINGDB
SALL4
Tbio
Family: TF
Novelty: 0.00211387
Score: 0.934
Data Source: STRINGDB
PPARG
Tclin
Family: NR
Novelty: 0.00012454
Score: 0.926
Data Source: STRINGDB
PHC1
Tbio
Novelty: 0.02755105
Score: 0.926
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00083441
Score: 0.924
Data Source: STRINGDB
REST
Tbio
Family: TF
Novelty: 0.00269947
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  271.51

PubMed score by year
PubTator Score  649.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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