Tbio ANXA11 Annexin A11

Protein Summary

Description

Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• P50995
• B4DVE7

Gene Name

• ANXA11

Ensembl ID

• ENST00000265447
• ENSP00000265447
• ENSG00000122359
• ENST00000372231
• ENSP00000361305
• ENST00000422982
• ENSP00000404412
• ENST00000438331
• ENSP00000398610

Symbol

• ANX11
• ALS23
• ANX11
• CAP50
• CAP-50

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
interacting protein	0.98
kinase perturbation	0.95
transcription factor binding site profile	0.88
molecular function	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.63   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 285   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.63   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (98)

Explore Interacting Targets

1 – 10 of 98

• See Interactions on String-DB

CST6

Tbio

Novelty:  0.02811473

p_int:  0.888113889

p_ni:  0.110844958

p_wrong:  0.001041153

Score:  0.346

Data Source:  BioPlex,STRINGDB

ANXA2

Tbio

Novelty:  0.00103362

Score:  0.877

Data Source:  STRINGDB

STXBP2

Tbio

Novelty:  0.01896992

Score:  0.872

Data Source:  STRINGDB

SLC9A3R2

Tbio

Family:  Transporter

Novelty:  0.01401705

Score:  0.865

Data Source:  STRINGDB

S100A6

Tbio

Novelty:  0.00176164

Score:  0.837

Data Source:  STRINGDB

ANXA3

Tbio

Novelty:  0.00615077

Score:  0.824

Data Source:  STRINGDB

DYSF

Tbio

Novelty:  0.00248634

Score:  0.75

Data Source:  STRINGDB

PLAC9

Tdark

Novelty:  0.23764669

Score:  0.743

Data Source:  STRINGDB

PDCD6

Tbio

Novelty:  0.0139857

Score:  0.74

Data Source:  STRINGDB

EWSR1

Tbio

Novelty:  0.00068411

Score:  0.723

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

PathwayCommons (1)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: netpath	TCR	258 targets	PathwayCommons: netpath

Name	Explore in Pharos	Explore in Source
TCR	258 targets	PathwayCommons: netpath

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (23)

Functions (7)

Components (13)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
calcium-dependent protein binding	Inferred from Physical Interaction (IPI)	UniProtKB
S100 protein binding	Inferred from Physical Interaction (IPI)	UniProtKB
MHC class II protein complex binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
calcium ion binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
calcium-dependent phospholipid binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphatidylethanolamine binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
vitamin D measurement	EFO_0004631	3	2	3		57.1
serum urea measurement	EFO_0009795	1	1	1		37.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
vitamin D measurement	EFO_0004631	3		57.1
serum urea measurement	EFO_0009795	1		37.6

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Amyotrophic lateral sclerosis
Annexin
Calcium
Calcium/phospholipid-binding
Cell cycle
Cell division
Complete proteome
Cytoplasm

GWAS Trait Find Similar Targets

No Header	No Header
serum urea measurement
vitamin D measurement

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	annexin A11		707628
Mouse	annexin A11	MGI:108481	11744
Rat	annexin A11	RGD:1309911	290527
Dog	annexin A11	VGNC:37938	479259
Horse	annexin A11	VGNC:15360	100064425

Species	Name	OMA	EggNOG	Inparanoid
Macaque	annexin A11
Mouse	annexin A11
Rat	annexin A11
Dog	annexin A11
Horse	annexin A11

Publication Statistics

PubMed Score 113.63

PubMed score by year

Reset Zoom

PubTator Score 44.23

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (58)

GeneRif Annotations (27)

Items per page:

10

0 of 0

PMID	Year	Title