Protein Summary
Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]
- ENST00000265447
- ENSP00000265447
- ENSG00000122359
- ENST00000372231
- ENSP00000361305
- ENST00000422982
- ENSP00000404412
- ENST00000438331
- ENSP00000398610
- ANX11
- ALS23
- ANX11
- CAP50
- CAP-50
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.99 | ||
interacting protein | 0.98 | ||
kinase perturbation | 0.95 | ||
transcription factor binding site profile | 0.88 | ||
molecular function | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 113.63 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 285 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 113.63 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 285 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (98)
CST6
Novelty: 0.02811473
p_int: 0.888113889
p_ni: 0.110844958
p_wrong: 0.001041153
Score: 0.346
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
PathwayCommons (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
PathwayCommons: netpath | TCR | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
TCR | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (7)
Components (13)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 3 | 2 | 3 | 57.1 | |||||
serum urea measurement | 1 | 1 | 1 | 37.6 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
vitamin D measurement | 3 | 57.1 | |||||
serum urea measurement | 1 | 37.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | annexin A11 | 707628 | ||||||
Mouse | MGI:108481 | 11744 | ||||||
Rat | RGD:1309911 | 290527 | ||||||
Dog | annexin A11 | VGNC:37938 | 479259 | |||||
Horse | annexin A11 | VGNC:15360 | 100064425 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | annexin A11 | |||||
Mouse | ||||||
Rat | ||||||
Dog | annexin A11 | |||||
Horse | annexin A11 | |||||
Publication Statistics
PubMed Score 113.63
PubMed score by year
PubTator Score 44.23
PubTator score by year
Related Publications
Text Mined References (58)
GeneRif Annotations (27)
Items per page:
0 of 0
PMID | Year | Title |
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