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Tbio
RASSF2
Ras association domain-containing protein 2

Protein Summary
Description
Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379376
  • ENSP00000368684
  • ENSG00000101265
  • ENST00000379400
  • ENSP00000368710

Symbol
  • CENP-34
  • KIAA0168
  • CENP-34
  • RASFADIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.89
drug perturbation
0.87
microRNA
0.8
tissue sample
0.68
gene perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.47   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.47   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
STK3
Tchem
Family:  Kinase
Novelty:  0.0529257
p_int:  0.9999997
p_ni:  3e-7
Score:  0.962
Data Source:  BioPlex,STRINGDB
STK4
Tchem
Family:  Kinase
Novelty:  0.02104423
p_int:  0.999999648
p_ni:  3.52e-7
Score:  0.848
Data Source:  BioPlex,STRINGDB
PPP1R9A
Tbio
Novelty:  0.04851082
p_int:  0.99964816
p_ni:  0.00035184
Score:  0.216
Data Source:  BioPlex,STRINGDB
PPP3CA
Tchem
Family:  Enzyme
Novelty:  0.00234189
p_int:  0.796503564
p_ni:  0.203496436
Score:  0.22
Data Source:  BioPlex,STRINGDB
YWHAG
Tchem
Novelty:  0.00845572
p_int:  0.769268775
p_ni:  0.230731225
Score:  0.175
Data Source:  BioPlex,STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.931
Data Source:  STRINGDB
RASSF4
Tbio
Novelty:  0.71626048
Score:  0.814
Data Source:  STRINGDB
RASSF7
Tbio
Novelty:  0.08011259
Score:  0.813
Data Source:  STRINGDB
RASSF10
Tbio
Novelty:  0.05161283
Score:  0.683
Data Source:  STRINGDB
C18orf21
Tdark
Novelty:  0.65363998
Score:  0.681
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sporadic Creutzfeld Jacob disease
2
2
0
1.3
79.2
DNA methylation
1
1
1
49.5
KANNO antigen measurement
1
1
0
1060
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sporadic Creutzfeld Jacob disease
0
1.3
79.2
DNA methylation
1
49.5
KANNO antigen measurement
0
1060
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras association domain family member 2
VGNC:9964
458077
Macaque
Ras association domain family member 2
718924
Mouse
MGI:2442060
215653
Rat
RGD:1305551
311437
Dog
Ras association domain family member 2
VGNC:45380
485781
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras association domain family member 2
Macaque
Ras association domain family member 2
Mouse
Rat
Dog
Ras association domain family member 2
Publication Statistics
PubMed Score 37.47
PubMed score by year
PubTator Score 30.62
PubTator score by year
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Related Publications
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PMID
Year
Title