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Tbio
RASSF2
Ras association domain-containing protein 2

Protein Summary
Description
Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379376
  • ENSP00000368684
  • ENSG00000101265
  • ENST00000379400
  • ENSP00000368710

Symbol
  • CENP-34
  • KIAA0168
  • CENP-34
  • RASFADIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.89
drug perturbation
0.87
microRNA
0.8
tissue sample
0.68
gene perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.79   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.79   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
DNA methylation
1
1
1
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
DNA methylation
1
77.7
Gene Ontology Terms (25)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Genetic Interaction (IGI)
MGI
Protein-Protein Interactions (65)
1 – 10 of 65
STK3
Tchem
Family: Kinase
Novelty: 0.0529257
p_int: 0.9999997
p_ni: 3e-7
Score: 0.962
Data Source: BioPlex,STRINGDB
STK4
Tchem
Family: Kinase
Novelty: 0.02104423
p_int: 0.999999648
p_ni: 3.52e-7
Score: 0.848
Data Source: BioPlex,STRINGDB
PPP1R9A
Tbio
Novelty: 0.04851082
p_int: 0.99964816
p_ni: 0.00035184
Score: 0.216
Data Source: BioPlex,STRINGDB
PPP3CA
Tchem
Family: Enzyme
Novelty: 0.00234189
p_int: 0.796503564
p_ni: 0.203496436
Score: 0.22
Data Source: BioPlex,STRINGDB
YWHAG
Tbio
Novelty: 0.00845572
p_int: 0.769268775
p_ni: 0.230731225
Score: 0.175
Data Source: BioPlex,STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.931
Data Source: STRINGDB
RASSF4
Tbio
Novelty: 0.71626048
Score: 0.814
Data Source: STRINGDB
RASSF7
Tbio
Novelty: 0.08011259
Score: 0.813
Data Source: STRINGDB
RASSF10
Tbio
Novelty: 0.05161283
Score: 0.683
Data Source: STRINGDB
C18orf21
Tdark
Novelty: 0.65363998
Score: 0.681
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.79

PubMed score by year
PubTator Score  30.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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