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Tbio
MNX1
Motor neuron and pancreas homeobox protein 1

Protein Summary
Description
Putative transcription factor involved in pancreas development and function. This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252971
  • ENSP00000252971
  • ENSG00000130675
  • ENST00000543409
  • ENSP00000438552

Symbol
  • HLXB9
  • HB9
  • HLXB9
  • SCRA1
  • HOXHB9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.84
virus perturbation
0.79
transcription factor binding site profile
0.71
PubMedID
0.65
small molecule perturbation
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.75   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.75   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (55)
1 – 10 of 55
PTF1A
Tbio
Family: TF
Novelty: 0.00593299
Score: 0.795
Data Source: STRINGDB
ISL1
Tbio
Family: TF
Novelty: 0.00169431
Score: 0.782
Data Source: STRINGDB
ISL2
Tbio
Family: TF
Novelty: 0.03917372
Score: 0.729
Data Source: STRINGDB
GDF11
Tclin
Novelty: 0.00585981
Score: 0.721
Data Source: STRINGDB
GDPD5
Tbio
Family: Enzyme
Novelty: 0.05871733
Score: 0.715
Data Source: STRINGDB
LHX3
Tbio
Family: TF
Novelty: 0.00784158
Score: 0.674
Data Source: STRINGDB
NEUROG3
Tbio
Family: TF
Novelty: 0.00341077
Score: 0.669
Data Source: STRINGDB
OLIG2
Tbio
Family: TF
Novelty: 0.0015221
Score: 0.666
Data Source: STRINGDB
RNF32
Tdark
Novelty: 0.21111273
Score: 0.654
Data Source: STRINGDB
KIDINS220
Tbio
Family: Enzyme
Novelty: 0.02169147
Score: 0.644
Data Source: STRINGDB
Publication Statistics
PubMed Score  139.75

PubMed score by year
PubTator Score  112.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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