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Tbio
EVX1
Homeobox even-skipped homolog protein 1

Protein Summary
Description
May play a role in the specification of neuronal cell types. This gene encodes a member of the even-skipped homeobox family characterized by the presence of a homeodomain closely related to the Drosophila even-skipped (eve) segmentation gene of the pair-rule class. The encoded protein may play an important role as a transcriptional repressor during embryogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000496902
  • ENSP00000419266
  • ENSG00000106038

Symbol
  • EVX-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
PubMedID
0.64
transcription factor
0.62
protein domain
0.58
transcription factor binding site profile
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.39   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.39   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
7.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
7.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
even-skipped homeobox 1
VGNC:14008
472327
Mouse
MGI:95461
14028
Dog
even-skipped homeobox 1
VGNC:40506
482376
Horse
even-skipped homeobox 1 [Source:HGNC Symbol;Acc:HGNC:3506]
Cow
even-skipped homeobox 1
VGNC:28637
540239
Species
Name
OMA
EggNOG
Inparanoid
Chimp
even-skipped homeobox 1
Mouse
Dog
even-skipped homeobox 1
Horse
even-skipped homeobox 1 [Source:HGNC Symbol;Acc:HGNC:3506]
Cow
even-skipped homeobox 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49640-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (55)
1 – 10 of 55
FOXB1
Tbio
Family: TF
Novelty: 0.04489092
Score: 0.682
Data Source: STRINGDB
SPATA31D1
Tdark
Novelty: 1.43869343
Score: 0.678
Data Source: STRINGDB
UTS2R
Tchem
Family: GPCR
Novelty: 0.00865846
Score: 0.668
Data Source: STRINGDB
PRDM12
Tbio
Family: TF; Epigenetic
Novelty: 0.0548291
Score: 0.652
Data Source: STRINGDB
SPOP
Tbio
Novelty: 0.00663363
Score: 0.649
Data Source: STRINGDB
PLEC
Tbio
Novelty: 0.00223244
Score: 0.626
Data Source: STRINGDB
ISL1
Tbio
Family: TF
Novelty: 0.00169431
Score: 0.622
Data Source: STRINGDB
LHX3
Tbio
Family: TF
Novelty: 0.00784158
Score: 0.61
Data Source: STRINGDB
RERE
Tbio
Family: TF
Novelty: 0.03065098
Score: 0.599
Data Source: STRINGDB
GATA2
Tbio
Family: TF
Novelty: 0.00153967
Score: 0.577
Data Source: STRINGDB
Publication Statistics
PubMed Score  35.39

PubMed score by year
PubTator Score  14.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer