You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SOX5
Transcription factor SOX-5

Protein Summary
Description
Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro. This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381381
  • ENSP00000370788
  • ENSG00000134532
  • ENST00000396007
  • ENSP00000379328
  • ENST00000451604
  • ENSP00000398273
  • ENST00000541536
  • ENSP00000441973
  • ENST00000545921
  • ENSP00000443520
  • ENST00000546136
  • ENSP00000437487
  • ENST00000646273
  • ENSP00000493866

Symbol
  • L-SOX5
  • LAMSHF
  • L-SOX5B
  • L-SOX5F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
biological process
0.86
transcription factor
0.84
microRNA
0.8
histone modification site profile
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.05   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.05   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
4
8
99
C-reactive protein measurement
1
3
3
96.6
body mass index
3
4
4
92.6
unipolar depression
4
3
0
1
91.1
Back pain
1
1
0
1.1
86.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
8
99
C-reactive protein measurement
3
96.6
body mass index
4
92.6
unipolar depression
0
1
91.1
Back pain
0
1.1
86.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SRY-box 5
VGNC:13451
740110
Macaque
SRY-box 5
707116
Mouse
MGI:98367
20678
Rat
RGD:620471
140587
Dog
SRY-box 5
VGNC:46681
486635
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SRY-box 5
Macaque
SRY-box 5
Mouse
Rat
Dog
SRY-box 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35711-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Neural Crest Differentiation
WikiPathways
Endochondral Ossification
WikiPathways
Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS
Name
Explore in Pharos
Explore in Source
Neural Crest Differentiation
Endochondral Ossification
Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS
Protein-Protein Interactions (111)
1 – 10 of 111
SOX6
Tbio
Family: TF
Novelty: 0.00484243
p_int: 1
Score: 0.568
Data Source: BioPlex,STRINGDB
SOX13
Tbio
Family: TF
Novelty: 0.02397048
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.858
Data Source: BioPlex,STRINGDB
CEP85
Tdark
Novelty: 0.2789146
p_int: 0.999730962
p_ni: 0.000269038
p_wrong: 1e-9
Score: 0.827
Data Source: BioPlex,STRINGDB
SOX1
Tbio
Family: TF
Novelty: 0.0045679
p_int: 0.990679215
p_wrong: 0.009320785
Score: 0.574
Data Source: BioPlex,STRINGDB
ANKRD40
Tdark
Novelty: 1.06633958
p_int: 0.977851469
p_ni: 0.022148531
Score: 0.163
Data Source: BioPlex,STRINGDB
SOX11
Tbio
Family: TF
Novelty: 0.00516158
p_int: 0.810335585
p_wrong: 0.189664415
Score: 0.59
Data Source: BioPlex,STRINGDB
ARID5A
Tbio
Family: TF
Novelty: 0.1061078
Score: 0.806
Data Source: STRINGDB
ETNK1
Tbio
Family: Kinase
Novelty: 0.04817798
Score: 0.8
Data Source: STRINGDB
COL2A1
Tbio
Novelty: 0.0011102
Score: 0.745
Data Source: STRINGDB
NEUROG1
Tbio
Family: TF
Novelty: 0.00494095
Score: 0.718
Data Source: STRINGDB
Publication Statistics
PubMed Score  164.05

PubMed score by year
PubTator Score  76.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: