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Tbio
HOXD12
Homeobox protein Hox-D12

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000406506
  • ENSP00000385586
  • ENSG00000170178

Symbol
  • HOX4H
  • HOX4H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
tissue
0.58
gene perturbation
0.53
PubMedID
0.51
biological process
0.48


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.68   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.68   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox D12
VGNC:1964
459760
Macaque
homeobox D12
100428778
Mouse
MGI:96204
15432
Rat
RGD:1309797
366082
Dog
homeobox D12
VGNC:41764
488413
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox D12
Macaque
homeobox D12
Mouse
Rat
Dog
homeobox D12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35452-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (30)
1 – 10 of 30
HAND2
Tbio
Family: TF
Novelty: 0.00478924
Score: 0.689
Data Source: STRINGDB
ZP2
Tbio
Novelty: 0.00310166
Score: 0.628
Data Source: STRINGDB
PBX2
Tbio
Family: TF
Novelty: 0.01339291
Score: 0.624
Data Source: STRINGDB
MEIS1
Tbio
Family: TF
Novelty: 0.00480433
Score: 0.611
Data Source: STRINGDB
LNPK
Tbio
Novelty: 0.07736762
Score: 0.589
Data Source: STRINGDB
MAFF
Tbio
Family: TF
Novelty: 0.01974936
Score: 0.563
Data Source: STRINGDB
SHH
Tchem
Novelty: 0.00028347
Score: 0.558
Data Source: STRINGDB
MAFK
Tbio
Family: TF
Novelty: 0.01735942
Score: 0.556
Data Source: STRINGDB
MAFG
Tbio
Family: TF
Novelty: 0.01605125
Score: 0.555
Data Source: STRINGDB
MAF
Tbio
Family: TF
Novelty: 0.00040887
Score: 0.541
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.68

PubMed score by year
PubTator Score  7.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer