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Tbio
BMP8B
Bone morphogenetic protein 8B

Protein Summary
Description
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372827
  • ENSP00000361915
  • ENSG00000116985

Symbol
  • BMP8
  • OP2
  • BMP8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
PubMedID
0.67
cell line
0.63
tissue sample
0.61
biological process
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 305.2   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 274   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 305.2   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
44.2
red blood cell density measurement
1
1
1
12.4
balding measurement
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
44.2
red blood cell density measurement
1
12.4
balding measurement
1
6.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:104515
12163
Rat
RGD:1585858
680931
Dog
bone morphogenetic protein 8B
100855618
Horse
bone morphogenetic protein 8a
100068680
Opossum
bone morphogenetic protein 8B
100031977
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
bone morphogenetic protein 8B
Horse
bone morphogenetic protein 8a
Opossum
bone morphogenetic protein 8B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P34820-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (116)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
TGF-beta signaling pathway
KEGG
Thermogenesis
KEGG
Hippo signaling pathway
KEGG
Cytokine-cytokine receptor interaction
Name
Explore in Pharos
Explore in Source
TGF-beta signaling pathway
Thermogenesis
Hippo signaling pathway
Cytokine-cytokine receptor interaction
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (41)
1 – 10 of 41
OS9
Tbio
Novelty:  0.01490339
p_int:  0.999133041
p_ni:  0.00040188
p_wrong:  0.000465079
Data Source:  BioPlex
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.908825831
p_ni:  0.002799258
p_wrong:  0.088374911
Score:  0.665
Data Source:  BioPlex,STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.802871137
p_ni:  0.000124288
p_wrong:  0.197004575
Score:  0.622
Data Source:  BioPlex,STRINGDB
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.765790595
p_ni:  0.000428153
p_wrong:  0.233781252
Data Source:  BioPlex
BMPR2
Tchem
Family:  Kinase
Novelty:  0.00155912
Score:  0.826
Data Source:  STRINGDB
BMPR1A
Tchem
Family:  Kinase
Novelty:  0.00343928
Score:  0.824
Data Source:  STRINGDB
BMPR1B
Tchem
Family:  Kinase
Novelty:  0.00698763
Score:  0.822
Data Source:  STRINGDB
BMP8A
Tbio
Novelty:  0.11863703
Score:  0.8
Data Source:  STRINGDB
NOG
Tbio
Novelty:  0.0010373
Score:  0.773
Data Source:  STRINGDB
OXCT2
Tbio
Family:  Enzyme
Novelty:  0.08045369
Score:  0.757
Data Source:  STRINGDB
Publication Statistics
PubMed Score  305.20

PubMed score by year
PubTator Score  62.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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