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Tbio
MAN1A1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

Protein Classes
Protein Summary
Description
Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368468
  • ENSP00000357453
  • ENSG00000111885

Symbol
  • MAN9
  • HUMM3
  • HUMM9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
kinase perturbation
0.93
transcription factor binding site profile
0.93
gene perturbation
0.91
disease perturbation
0.9


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.94   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.94   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannosidase alpha class 1A member 1
VGNC:7191
463148
Macaque
mannosidase alpha class 1A member 1
714609
Mouse
MGI:104677
17155
Rat
RGD:1310891
294410
Dog
mannosidase alpha class 1A member 1
VGNC:42942
476275
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannosidase alpha class 1A member 1
Macaque
mannosidase alpha class 1A member 1
Mouse
Rat
Dog
mannosidase alpha class 1A member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P33908-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Metabolism of proteins
Protein-Protein Interactions (100)
1 – 10 of 100
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.999939093
p_ni:  0.000060907
Data Source:  BioPlex
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.999934346
p_ni:  0.000065654
Data Source:  BioPlex
CLDND1
Tbio
Novelty:  0.06681793
p_int:  0.999620231
p_ni:  0.000301609
p_wrong:  0.000078161
Score:  0.209
Data Source:  BioPlex,STRINGDB
LRRC24
Tdark
Novelty:  2.61911627
p_int:  0.998706143
p_ni:  0.001241238
p_wrong:  0.000052619
Data Source:  BioPlex
CDCP1
Tbio
Novelty:  0.01385067
p_int:  0.992461352
p_ni:  0.007538648
Score:  0.232
Data Source:  BioPlex,STRINGDB
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.98487282
p_ni:  0.01512718
Data Source:  BioPlex
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.984826292
p_ni:  0.015173707
p_wrong:  2e-9
Data Source:  BioPlex
MGAT2
Tchem
Family:  Enzyme
Novelty:  0.02440696
p_int:  0.979652051
p_ni:  0.020347949
Score:  0.23
Data Source:  BioPlex,STRINGDB
CLU
Tbio
Novelty:  0.00054776
p_int:  0.977985163
p_ni:  0.022014835
p_wrong:  2e-9
Data Source:  BioPlex
NLGN2
Tbio
Family:  Enzyme
Novelty:  0.01613168
p_int:  0.971600928
p_ni:  0.028387641
p_wrong:  0.000011431
Data Source:  BioPlex
Publication Statistics
PubMed Score  149.94

PubMed score by year
PubTator Score  99.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer