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Tbio
TM4SF1
Transmembrane 4 L6 family member 1

Protein Summary
Description
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305366
  • ENSP00000304277
  • ENSG00000169908

Symbol
  • M3S1
  • TAAL6
  • L6
  • H-L6
  • M3S1
  • TAAL6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
gene perturbation
0.95
virus perturbation
0.92
small molecule perturbation
0.9
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.86   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.86   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
1
1
0
9.9
32.7
serum gamma-glutamyl transferase measurement
1
1
1
17.5
platelet crit
1
1
1
13.1
low density lipoprotein cholesterol measurement
1
1
1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
0
9.9
32.7
serum gamma-glutamyl transferase measurement
1
17.5
platelet crit
1
13.1
low density lipoprotein cholesterol measurement
1
1.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane 4 L six family member 1
VGNC:7131
460770
Macaque
transmembrane 4 L six family member 1
711908
Mouse
MGI:104678
17112
Rat
RGD:1309652
295061
Dog
transmembrane 4 L six family member 1
VGNC:52907
485710
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane 4 L six family member 1
Macaque
transmembrane 4 L six family member 1
Mouse
Rat
Dog
transmembrane 4 L six family member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P30408-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (36)
1 – 10 of 36
CD63
Tchem
Novelty:  0.00072515
Score:  0.715
Data Source:  STRINGDB
C1D
Tbio
Novelty:  0.00997109
Score:  0.714
Data Source:  STRINGDB
DDR1
Tchem
Family:  Kinase
Novelty:  0.00432488
Score:  0.693
Data Source:  STRINGDB
TSPAN1
Tbio
Novelty:  0.01547855
Score:  0.67
Data Source:  STRINGDB
TSPAN4
Tbio
Novelty:  0.03394894
Score:  0.655
Data Source:  STRINGDB
CD53
Tbio
Novelty:  0.01722633
Score:  0.64
Data Source:  STRINGDB
MYO10
Tbio
Novelty:  0.0233015
Score:  0.629
Data Source:  STRINGDB
CD37
Tbio
Novelty:  0.00754559
Score:  0.628
Data Source:  STRINGDB
RHBG
Tbio
Novelty:  0.01752773
Score:  0.627
Data Source:  STRINGDB
TSPAN31
Tbio
Novelty:  0.13580467
Score:  0.623
Data Source:  STRINGDB
Publication Statistics
PubMed Score  55.86

PubMed score by year
PubTator Score  126.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer