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Tbio
CALB2
Calretinin

Protein Summary
Description
Calretinin is a calcium-binding protein which is abundant in auditory neurons. This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302628
  • ENSP00000307508
  • ENSG00000172137
  • ENST00000635371
  • ENSP00000488916
  • ENSG00000282830

Symbol
  • CAB29
  • CR
  • CAL2
  • CAB29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
PubMedID
0.79
transcription factor perturbation
0.74
biological term
0.7
virus perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1908.36   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 578   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1908.36   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calbindin 2
VGNC:13672
454224
Mouse
MGI:101914
12308
Rat
RGD:620981
117059
Dog
calbindin 2
VGNC:38661
610586
Horse
calbindin 2
VGNC:16004
100068401
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calbindin 2
Mouse
Rat
Dog
calbindin 2
Horse
calbindin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P22676-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (216)
1 – 10 of 216
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.99985704
p_ni: 0.000110768
p_wrong: 0.000032192
Data Source: BioPlex
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.999827682
p_ni: 0.000141119
p_wrong: 0.000031199
Data Source: BioPlex
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.995575579
p_ni: 0.003470536
p_wrong: 0.000953885
Score: 0.181
Data Source: BioPlex,STRINGDB
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.874398106
p_ni: 0.000115129
p_wrong: 0.125486765
Data Source: BioPlex
PVALB
Tbio
Novelty: 0.00024439
Score: 0.944
Data Source: STRINGDB
SST
Tbio
Novelty: 0.00005944
Score: 0.857
Data Source: STRINGDB
GAD1
Tbio
Family: Enzyme
Novelty: 0.00067443
Score: 0.827
Data Source: STRINGDB
TH
Tclin
Family: Enzyme
Novelty: 0.00025719
Score: 0.796
Data Source: STRINGDB
NPY
Tbio
Novelty: 0.00012637
Score: 0.79
Data Source: STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.769
Data Source: STRINGDB
Publication Statistics
PubMed Score  1908.36

PubMed score by year
PubTator Score  782.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer