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Tbio
HCLS1
Hematopoietic lineage cell-specific protein

Protein Summary
Description
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314583
  • ENSP00000320176
  • ENSG00000180353
  • ENST00000495491
  • ENSP00000418299

Symbol
  • HS1
  • HS1
  • p75
  • CTTNL
  • lckBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.87
gene perturbation
0.81
kinase
0.78
virus perturbation
0.76
hub protein
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.63   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 428   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.63   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
8
8
97.8
mean platelet volume
2
2
2
83
mean reticulocyte volume
1
1
1
53.3
mean corpuscular hemoglobin concentration
1
1
1
45.2
mean corpuscular volume
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
8
97.8
mean platelet volume
2
83
mean reticulocyte volume
1
53.3
mean corpuscular hemoglobin concentration
1
45.2
mean corpuscular volume
1
30.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hematopoietic cell-specific Lyn substrate 1
460623
Macaque
hematopoietic cell-specific Lyn substrate 1
714044
Mouse
MGI:104568
15163
Rat
RGD:1304754
288077
Dog
hematopoietic cell-specific Lyn substrate 1
VGNC:41619
100684969
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hematopoietic cell-specific Lyn substrate 1
Macaque
hematopoietic cell-specific Lyn substrate 1
Mouse
Rat
Dog
hematopoietic cell-specific Lyn substrate 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P14317-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Tight junction
KEGG
Bacterial invasion of epithelial cells
KEGG
Shigellosis
KEGG
Pathogenic Escherichia coli infection
KEGG
Proteoglycans in cancer
Name
Explore in Pharos
Explore in Source
Tight junction
Bacterial invasion of epithelial cells
Shigellosis
Pathogenic Escherichia coli infection
Proteoglycans in cancer
Gene Ontology Terms (32)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (120)
1 – 10 of 120
SNX1
Tbio
Novelty:  0.01267973
p_int:  0.998990546
p_ni:  0.001009452
p_wrong:  2e-9
Score:  0.691
Data Source:  BioPlex,STRINGDB
SNCA
Tchem
Novelty:  0.00012042
p_int:  0.915728689
p_ni:  0.006128783
p_wrong:  0.078142528
Score:  0.269
Data Source:  BioPlex,STRINGDB
SNX5
Tbio
Novelty:  0.04075649
p_int:  0.858206565
p_ni:  0.141793433
p_wrong:  2e-9
Score:  0.812
Data Source:  BioPlex,STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.981
Data Source:  STRINGDB
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.976
Data Source:  STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.927
Data Source:  STRINGDB
FCER1A
Tbio
Novelty:  0.00362182
Score:  0.916
Data Source:  STRINGDB
MS4A2
Tbio
Novelty:  0.07049421
Score:  0.9
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.899
Data Source:  STRINGDB
DNM2
Tchem
Novelty:  0.00265965
Score:  0.885
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.63

PubMed score by year
PubTator Score  37.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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