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Tclin
CALCB
Calcitonin gene-related peptide 2

Protein Summary
Description
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324229
  • ENSP00000346017
  • ENSG00000175868
  • ENST00000533448
  • ENSP00000433490

Symbol
  • CALC2
  • CALC2
  • CGRP2
  • CGRP-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
protein domain
0.73
disease perturbation
0.62
tissue
0.58
histone modification site profile
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.1   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.1   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
eptinezumab
no chemical structure image available
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
7
11
99.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
11
99.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcitonin related polypeptide beta
VGNC:7798
451044
Macaque
calcitonin gene-related peptide 2
698209
Mouse
MGI:2151254
116903
Rat
RGD:620997
171519
Dog
calcitonin-related polypeptide beta
403415
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcitonin related polypeptide beta
Macaque
calcitonin gene-related peptide 2
Mouse
Rat
Dog
calcitonin-related polypeptide beta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P10092-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Calcitonin-like ligand receptors (R-HSA-419812)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Calcitonin-like ligand receptors
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Calcitonin-like ligand receptors
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (131)
1 – 10 of 131
GIP
Tchem
Novelty: 0.0007219
p_int: 0.997104137
p_ni: 8.67e-7
p_wrong: 0.002894996
Score: 0.9
Data Source: BioPlex,STRINGDB
CALCA
Tclin
Novelty: 0.00010496
p_int: 0.959087989
p_ni: 8e-9
p_wrong: 0.040912003
Score: 0.909
Data Source: BioPlex,STRINGDB
GINM1
Tdark
Novelty: 1.0701107
p_int: 0.908660843
p_ni: 2.23e-7
p_wrong: 0.091338934
Score: 0.221
Data Source: BioPlex,STRINGDB
ACTA2
Tbio
Novelty: 0.00199354
p_int: 0.855098813
p_ni: 0.000529932
p_wrong: 0.144371255
Data Source: BioPlex
IAPP
Tbio
Novelty: 0.0005195
Score: 0.982
Data Source: STRINGDB
ADM
Tbio
Novelty: 0.0004958
Score: 0.974
Data Source: STRINGDB
RAMP1
Tclin
Novelty: 0.00831253
Score: 0.974
Data Source: Reactome,STRINGDB
RAMP2
Tclin
Novelty: 0.01086538
Score: 0.974
Data Source: STRINGDB
CALCR
Tclin
Family: GPCR
Novelty: 0.00112487
Score: 0.97
Data Source: STRINGDB
CALCRL
Tclin
Family: GPCR
Novelty: 0.00568602
Score: 0.97
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  43.10

PubMed score by year
PubTator Score  59.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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