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Tdark
TMEM253
Transmembrane protein 253

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000418511
  • ENSP00000453962
  • ENSG00000232070
  • ENST00000556585
  • ENSP00000451229

Symbol
  • C14orf176
  • C14orf95
  • C14orf95
  • C14orf176
  • NCRNA00220
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.91
cell type or tissue
0.81
tissue
0.69
transcription factor
0.58
cell line
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.27   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.27   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
1
3
77.1
testosterone measurement
2
1
2
76.3
hemoglobin measurement
2
1
2
74.8
red blood cell density measurement
1
1
1
69.4
platelet crit
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
77.1
testosterone measurement
2
76.3
hemoglobin measurement
2
74.8
red blood cell density measurement
1
69.4
platelet crit
1
54.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 253
VGNC:12378
465213
Macaque
transmembrane protein 253
707525
Mouse
MGI:3588246
619301
Rat
RGD:1597322
690368
Dog
transmembrane protein 253
VGNC:47559
100688060
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 253
Macaque
transmembrane protein 253
Mouse
Rat
Dog
transmembrane protein 253
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P0C7T8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (7)
1 – 7 of 7
ARFGEF3
Tdark
Novelty:  0.20402365
Score:  0.733
Data Source:  STRINGDB
TRMO
Tbio
Novelty:  0.18313621
Score:  0.679
Data Source:  STRINGDB
PARP10
Tchem
Family:  Enzyme
Novelty:  0.03713719
Score:  0.557
Data Source:  STRINGDB
C8orf82
Tdark
Novelty:  3.49514563
Score:  0.556
Data Source:  STRINGDB
PSME1
Tbio
Novelty:  0.01258149
Score:  0.51
Data Source:  STRINGDB
FOXE1
Tbio
Family:  TF
Novelty:  0.00783938
Score:  0.44
Data Source:  STRINGDB
CCDC28B
Tbio
Novelty:  0.16787198
Score:  0.4
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.27

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer