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Tbio
CXCL14
C-X-C motif chemokine 14

Protein Summary
Description
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337225
  • ENSP00000337065
  • ENSG00000145824

Symbol
  • MIP2G
  • NJAC
  • SCYB14
  • KEC
  • KS1
  • BMAC
  • BRAK
  • NJAC
  • MIP2G
  • MIP-2g
  • SCYB14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
gene perturbation
0.96
disease
0.7
phenotype
0.64
biological term
0.61


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.57   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.57   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 14
VGNC:3960
471640
Macaque
C-X-C motif chemokine ligand 14
712076
Mouse
MGI:1888514
57266
Rat
RGD:1307406
306748
Dog
C-X-C motif chemokine ligand 14
VGNC:39748
610078
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 14
Macaque
C-X-C motif chemokine ligand 14
Mouse
Rat
Dog
C-X-C motif chemokine ligand 14
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95715-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Chemokine signaling pathway
KEGG
Cytokine-cytokine receptor interaction
KEGG
Viral protein interaction with cytokine and cytokine receptor
Name
Explore in Pharos
Explore in Source
Chemokine signaling pathway
Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (81)
1 – 10 of 81
CTNNBL1
Tbio
Novelty:  0.0189038
p_int:  0.999312325
p_ni:  0.000684821
p_wrong:  0.000002854
Data Source:  BioPlex
ACTR10
Tbio
Novelty:  0.11388846
p_int:  0.995994164
p_ni:  0.004005836
Data Source:  BioPlex
DCTN5
Tbio
Novelty:  0.19530162
p_int:  0.990562033
p_ni:  0.009199652
p_wrong:  0.000238315
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.989954387
p_ni:  0.009668533
p_wrong:  0.000377079
Data Source:  BioPlex
AK4
Tbio
Family:  Kinase
Novelty:  0.00977619
p_int:  0.958984514
p_ni:  0.036980366
p_wrong:  0.00403512
Data Source:  BioPlex
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.944135845
p_ni:  0.055672931
p_wrong:  0.000191224
Data Source:  BioPlex
RPRD1B
Tbio
Novelty:  0.0444394
p_int:  0.930613568
p_ni:  0.069385653
p_wrong:  7.78e-7
Data Source:  BioPlex
TRPM3
Tchem
Family:  IC
Novelty:  0.00647452
p_int:  0.921595851
p_ni:  0.011313884
p_wrong:  0.067090265
Data Source:  BioPlex
DCTN3
Tbio
Novelty:  0.14551388
p_int:  0.919429064
p_ni:  0.080570936
Data Source:  BioPlex
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.906212598
p_ni:  0.080170907
p_wrong:  0.013616495
Data Source:  BioPlex
Publication Statistics
PubMed Score  189.57

PubMed score by year
PubTator Score  94.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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