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Tdark
PPP1R3D
Protein phosphatase 1 regulatory subunit 3D

Protein Summary
Description
Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Phosphorylation of serine and threonine residues in proteins is a crucial step in the regulation of many cellular functions ranging from hormonal regulation to cell division and even short-term memory. The level of phosphorylation is controlled by the opposing actions of protein kinases and protein phosphatases. Protein phosphatase 1 (PP1) is 1 of 4 major serine/threonine-specific protein phosphatases which have been identified in eukaryotic cells. PP1 associates with various regulatory subunits that dictate its subcellular localization and modulate its substrate specificity. Several subunits that target PP1 to glycogen have been identified. This gene encodes a glycogen-targeting subunit of PP1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370996
  • ENSP00000360035
  • ENSG00000132825

Symbol
  • PPP1R6
  • PPP1R6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
transcription factor perturbation
0.8
cell line
0.66
transcription factor binding site profile
0.65
PubMedID
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.45   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 12   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.45   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999999836
p_ni:  1.7e-8
p_wrong:  1.48e-7
Score:  0.885
Data Source:  BioPlex,STRINGDB
PPP1R3C
Tbio
Family:  Enzyme
Novelty:  0.01784199
p_int:  0.999995
p_ni:  3.11e-7
p_wrong:  0.000004689
Score:  0.973
Data Source:  BioPlex,STRINGDB
STBD1
Tbio
Novelty:  0.08362185
p_int:  0.993991418
p_ni:  0.000050884
p_wrong:  0.005957698
Score:  0.858
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
Score:  0.942
Data Source:  STRINGDB
PPP1CB
Tbio
Family:  Enzyme
Novelty:  0.0122614
Score:  0.856
Data Source:  STRINGDB
PPP1R3F
Tbio
Family:  Enzyme
Novelty:  0.06150915
Score:  0.85
Data Source:  STRINGDB
PPP1R3A
Tbio
Family:  Enzyme
Novelty:  0.03534333
Score:  0.843
Data Source:  STRINGDB
PPP1R3B
Tbio
Family:  Enzyme
Novelty:  0.0244434
Score:  0.837
Data Source:  STRINGDB
PPP1R3E
Tdark
Family:  Enzyme
Novelty:  1.19260521
Score:  0.825
Data Source:  STRINGDB
FAM217B
Tdark
Novelty:  4.03122155
Score:  0.769
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 regulatory subunit 3D
701281
Mouse
MGI:1917664
228966
Rat
RGD:1586306
689995
Dog
protein phosphatase 1 regulatory subunit 3D
VGNC:44899
485953
Cow
protein phosphatase 1 regulatory subunit 3D
VGNC:33245
782160
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 regulatory subunit 3D
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 3D
Cow
protein phosphatase 1 regulatory subunit 3D
Publication Statistics
PubMed Score 2.45
PubMed score by year
PubTator Score 3.79
PubTator score by year
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Related Publications
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PMID
Year
Title