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Tchem
ADCY5
Adenylate cyclase type 5

Protein Summary
Description
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309879
  • ENSP00000308685
  • ENSG00000173175
  • ENST00000462833
  • ENSP00000419361

Symbol
  • AC5
  • FDFM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
molecular function
0.96
kinase perturbation
0.88
pathway
0.72
cell line
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.71   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.71   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
7
4
8
99.4
8
3
4
1.1
98.9
glucose tolerance test
1
1
1
87.9
lymphocyte count
3
2
3
86.4
monocyte count
2
2
2
85.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
8
99.4
4
1.1
98.9
glucose tolerance test
1
87.9
lymphocyte count
3
86.4
monocyte count
2
85.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenylate cyclase 5
VGNC:53353
470905
Macaque
adenylate cyclase 5
715897
Mouse
MGI:99673
224129
Rat
RGD:71014
64532
Dog
adenylate cyclase 5
VGNC:37622
403859
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenylate cyclase 5
Macaque
adenylate cyclase 5
Mouse
Rat
Dog
adenylate cyclase 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95622-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (115)
Activation of GABAB receptors (R-HSA-991365)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of GABAB receptors
Reactome
Adenylate cyclase activating pathway
Reactome
Adenylate cyclase inhibitory pathway
Reactome
Adrenaline,noradrenaline inhibits insulin secretion
Reactome
Aquaporin-mediated transport
Name
Explore in Pharos
Explore in Source
Activation of GABAB receptors
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Adrenaline,noradrenaline inhibits insulin secretion
Aquaporin-mediated transport
Gene Ontology Terms (25)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (507)
1 – 10 of 507
MTNR1B
Tclin
Family: GPCR
Novelty: 0.00646326
Score: 0.971
Data Source: STRINGDB
GIPR
Tchem
Family: GPCR
Novelty: 0.00961809
Score: 0.971
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.968
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.968
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.968
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.968
Data Source: STRINGDB
GNAL
Tbio
Novelty: 0.01757098
Score: 0.964
Data Source: STRINGDB
DRD1
Tclin
Family: GPCR
Novelty: 0.00165886
Score: 0.963
Data Source: STRINGDB
RAPGEF4
Tchem
Novelty: 0.00235788
Score: 0.962
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.96
Data Source: STRINGDB
Publication Statistics
PubMed Score  339.71

PubMed score by year
PubTator Score  94.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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