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Tbio
CLSTN1
Calsyntenin-1

Protein Summary
Description
Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity). This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361311
  • ENSP00000354997
  • ENSG00000171603
  • ENST00000377298
  • ENSP00000366513

Symbol
  • CS1
  • KIAA0911
  • CST-1
  • CSTN1
  • CDHR12
  • PIK3CD
  • ALC-ALPHA
  • XB31alpha
  • alcalpha1
  • alcalpha2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
virus perturbation
0.92
microRNA
0.74
transcription factor binding site profile
0.73
cellular component
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.98   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.98   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Splicing factor NOVA regulated synaptic proteins
Name
Explore in Pharos
Explore in Source
Splicing factor NOVA regulated synaptic proteins
Gene Ontology Terms (24)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (58)
1 – 10 of 58
CD160
Tbio
Novelty: 0.01511748
p_int: 0.999932199
p_ni: 0.000067801
Data Source: BioPlex
DEFA5
Tbio
Novelty: 0.00863727
p_int: 0.998933843
p_ni: 0.001066157
Data Source: BioPlex
SCGB1D1
Tbio
Novelty: 0.04199997
p_int: 0.998563916
p_ni: 0.001436084
Data Source: BioPlex
CSTL1
Tbio
Novelty: 0.13370814
p_int: 0.992196288
p_ni: 0.00780371
p_wrong: 2e-9
Data Source: BioPlex
APBA3
Tbio
Novelty: 0.05059532
p_int: 0.93351499
p_ni: 0.06648501
Score: 0.162
Data Source: BioPlex,STRINGDB
PVRIG
Tdark
Novelty: 0.28920924
p_int: 0.926823103
p_ni: 0.073176897
Score: 0.203
Data Source: BioPlex,STRINGDB
PCDHA4
Tdark
Novelty: 0.30511211
p_int: 0.917131507
p_ni: 0.082868493
Score: 0.163
Data Source: BioPlex,STRINGDB
SLAMF1
Tbio
Novelty: 0.00112892
p_int: 0.912479488
p_ni: 0.087520512
Data Source: BioPlex
CDCP1
Tbio
Novelty: 0.01385067
p_int: 0.906232639
p_ni: 0.093767361
Score: 0.34
Data Source: BioPlex,STRINGDB
LYPD5
Tdark
Novelty: 0.97576337
p_int: 0.895913492
p_ni: 0.104086508
Score: 0.252
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  31.98

PubMed score by year
PubTator Score  12.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer