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Tbio
TMCC1
Transmembrane and coiled-coil domains protein 1

Protein Summary
Description
Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393238
  • ENSP00000376930
  • ENSG00000172765

Symbol
  • KIAA0779
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.87
virus perturbation
0.83
transcription factor
0.68
cell type or tissue
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.44   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.44   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
13
29
47
98.9
waist-hip ratio
4
26
27
98.9
BMI-adjusted hip circumference
3
29
33
98.7
hip circumference
3
25
29
98.1
waist circumference
1
10
10
92.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
47
98.9
waist-hip ratio
27
98.9
BMI-adjusted hip circumference
33
98.7
hip circumference
29
98.1
waist circumference
10
92.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane and coiled-coil domain family 1
VGNC:7132
460688
Macaque
transmembrane and coiled-coil domain family 1
702576
Mouse
MGI:2442368
330401
Rat
RGD:1311909
312654
Dog
transmembrane and coiled-coil domain family 1
VGNC:47428
484644
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane and coiled-coil domain family 1
Macaque
transmembrane and coiled-coil domain family 1
Mouse
Rat
Dog
transmembrane and coiled-coil domain family 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O94876-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (51)
1 – 10 of 51
TEX28
Tdark
Novelty:  0.10581423
p_int:  1
Score:  0.395
Data Source:  BioPlex,STRINGDB
CFAP100
Tbio
Novelty:  0.11194637
Score:  0.809
Data Source:  STRINGDB
PODXL2
Tbio
Novelty:  0.09100487
Score:  0.809
Data Source:  STRINGDB
KLF15
Tbio
Family:  TF
Novelty:  0.009709
Score:  0.8
Data Source:  STRINGDB
PLXND1
Tbio
Novelty:  0.01249713
Score:  0.724
Data Source:  STRINGDB
TIMM17A
Tbio
Family:  Enzyme
Novelty:  0.02095904
Score:  0.697
Data Source:  STRINGDB
ITIH6
Tdark
Novelty:  4.5922884
Score:  0.667
Data Source:  STRINGDB
PLXNA1
Tbio
Novelty:  0.01195083
Score:  0.652
Data Source:  STRINGDB
CHCHD3
Tbio
Novelty:  0.05341939
Score:  0.646
Data Source:  STRINGDB
ITIH2
Tbio
Novelty:  0.04886358
Score:  0.64
Data Source:  STRINGDB
Publication Statistics
PubMed Score  6.44

PubMed score by year
PubTator Score  7.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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