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Tbio
MGRN1
E3 ubiquitin-protein ligase MGRN1

Protein Summary
Description
E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262370
  • ENSP00000262370
  • ENSG00000102858
  • ENST00000399577
  • ENSP00000382487
  • ENST00000415496
  • ENSP00000393311
  • ENST00000586183
  • ENSP00000465860
  • ENST00000588994
  • ENSP00000468819

Symbol
  • KIAA0544
  • RNF156
  • RNF156
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
transcription factor
0.74
cell type or tissue
0.66
cellular component
0.63
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.97   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.97   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (326)
PSG8
Tdark
Novelty:  0.1446257
p_int:  0.996456069
p_ni:  0.003543931
Score:  0.518
Data Source:  BioPlex,STRINGDB
ANKRD46
Tbio
Novelty:  0.06546845
p_int:  0.995693891
p_ni:  0.004138442
p_wrong:  0.000167668
Score:  0.314
Data Source:  BioPlex,STRINGDB
ATRN
Tbio
Novelty:  0.01017312
p_int:  0.987721101
p_ni:  0.012278899
Score:  0.992
Data Source:  BioPlex,STRINGDB
C9orf40
Tdark
Novelty:  2.72763898
p_int:  0.982554793
p_ni:  0.015810027
p_wrong:  0.001635181
Score:  0.241
Data Source:  BioPlex,STRINGDB
BTNL8
Tdark
Novelty:  0.40339869
p_int:  0.939735609
p_ni:  0.060264391
Data Source:  BioPlex
PDCD2
Tbio
Novelty:  0.05054811
p_int:  0.936001092
p_ni:  0.063998908
Score:  0.313
Data Source:  BioPlex,STRINGDB
INTS7
Tdark
Novelty:  0.04592325
p_int:  0.896480173
p_ni:  0.103410696
p_wrong:  0.00010913
Data Source:  BioPlex
HYOU1
Tbio
Novelty:  0.00833649
p_int:  0.895343653
p_ni:  0.104656347
Data Source:  BioPlex
TIMM29
Tdark
Novelty:  0.51321672
p_int:  0.891001107
p_ni:  0.108978579
p_wrong:  0.000020314
Data Source:  BioPlex
PATE1
Tbio
Novelty:  0.0705075
p_int:  0.889546899
p_ni:  0.110453101
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
89.1
waist circumference
1
4
4
60.8
hemoglobin measurement
2
1
2
51.4
high density lipoprotein cholesterol measurement
3
2
3
47.5
hematocrit
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
89.1
waist circumference
4
60.8
hemoglobin measurement
2
51.4
high density lipoprotein cholesterol measurement
3
47.5
hematocrit
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mahogunin ring finger 1
VGNC:9088
453884
Macaque
mahogunin ring finger 1
709272
Mouse
MGI:2447670
17237
Rat
RGD:1311862
302938
Dog
mahogunin ring finger 1
VGNC:43214
479863
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mahogunin ring finger 1
Macaque
mahogunin ring finger 1
Mouse
Rat
Dog
mahogunin ring finger 1
Publication Statistics
PubMed Score 28.97
PubMed score by year
PubTator Score 12.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title