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Tbio
GNRH2
Progonadoliberin-2

Protein Summary
Description
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. This gene is a member of the gonadotropin-releasing hormone (GnRH) gene family. Proteins encoded by members of this gene family are proteolytically cleaved to form neuropeptides which, in part, regulate reproductive functions by stimulating the production and release of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The human GNRH2 gene is predicted to encode a preproprotein from which a mature neuropeptide of 10 amino acids is cleaved. However, while the human genome retains the sequence for a functional GNRH2 decapeptide, translation of the human GNRH2 gene has not yet been demonstrated and the GNRH2 gene of chimpanzees, gorilla, and Sumatran orangutan have a premature stop at codon eight of the decapeptide sequence which suggests GNRH2 was a pseudogene in the hominid lineage. The GNRH2 gene is also believed to be a pseudoge ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245983
  • ENSP00000245983
  • ENSG00000125787
  • ENST00000359100
  • ENSP00000352003
  • ENST00000380346
  • ENSP00000369704
  • ENST00000380347
  • ENSP00000369705

Symbol
  • GnRH-II
  • LH-RHII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.6
tissue
0.59
biological term
0.51
cell type or tissue
0.46
gene perturbation
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 345.69   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 345.69   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (200)
GNRH1
Tbio
Novelty:  0.00020807
Score:  0.992
Data Source:  STRINGDB
GNRHR
Tclin
Family:  GPCR
Novelty:  0.00203671
Score:  0.979
Data Source:  Reactome,STRINGDB
KISS1
Tbio
Novelty:  0.00096537
Score:  0.961
Data Source:  STRINGDB
KISS1R
Tchem
Family:  GPCR
Novelty:  0.0026282
Score:  0.955
Data Source:  STRINGDB
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
Score:  0.952
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.95
Data Source:  STRINGDB
TAC3
Tchem
Novelty:  0.001685
Score:  0.949
Data Source:  STRINGDB
PROK2
Tbio
Novelty:  0.00512397
Score:  0.947
Data Source:  STRINGDB
NPFFR1
Tchem
Family:  GPCR
Novelty:  0.01950099
Score:  0.947
Data Source:  STRINGDB
OXTR
Tclin
Family:  GPCR
Novelty:  0.0007551
Score:  0.943
Data Source:  STRINGDB
Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Hormone ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Hormone ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
1
2
64.9
reticulocyte count
1
1
1
50.6
household income
2
1
2
37.6
body mass index
1
1
1
30.2
wellbeing measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
64.9
reticulocyte count
1
50.6
household income
2
37.6
body mass index
1
30.2
wellbeing measurement
1
17.8
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gonadotropin releasing hormone 2
VGNC:14137
746810
Macaque
gonadotropin releasing hormone 2
619516
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gonadotropin releasing hormone 2
Macaque
gonadotropin releasing hormone 2
Publication Statistics
PubMed Score 345.69
PubMed score by year
PubTator Score 124.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title