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Tbio
ATMIN
ATM interactor

Protein Summary
Description
Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299575
  • ENSP00000299575
  • ENSG00000166454
  • ENST00000564241
  • ENSP00000463478
  • ENST00000566488
  • ENSP00000455497

Symbol
  • KIAA0431
  • ZNF822
  • ASCIZ
  • ZNF822
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
microRNA
0.68
tissue sample
0.68
transcription factor perturbation
0.68
cell type or tissue
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.99   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.99   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
2
3
88.3
glycine measurement
4
2
4
86.7
amino acid measurement
2
2
2
69.6
mean corpuscular hemoglobin concentration
1
1
1
64.9
protein measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
88.3
glycine measurement
4
86.7
amino acid measurement
2
69.6
mean corpuscular hemoglobin concentration
1
64.9
protein measurement
1
57.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATM interactor
VGNC:13665
738730
Macaque
ATM interactor
717395
Mouse
MGI:2682328
234776
Dog
ATM interactor
VGNC:53265
100688833
Horse
ATM interactor
VGNC:49420
100069801
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATM interactor
Macaque
ATM interactor
Mouse
Dog
ATM interactor
Horse
ATM interactor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43313-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
ATM Signaling Network in Development and Disease
WikiPathways
ATM Signaling Network in Development and Disease
WikiPathways
ATM Signaling Network in Development and Disease
WikiPathways
ATM Signaling Network in Development and Disease
WikiPathways
miRNA Regulation of DNA Damage Response
Name
Explore in Pharos
Explore in Source
ATM Signaling Network in Development and Disease
ATM Signaling Network in Development and Disease
ATM Signaling Network in Development and Disease
ATM Signaling Network in Development and Disease
miRNA Regulation of DNA Damage Response
Protein-Protein Interactions (22)
1 – 10 of 22
CAPN13
Tdark
Novelty:  0.27206398
p_int:  0.999962502
p_ni:  0.000037498
Score:  0.331
Data Source:  BioPlex,STRINGDB
SPECC1L
Tbio
Novelty:  0.06116909
p_int:  0.980708775
p_ni:  0.019291225
Score:  0.216
Data Source:  BioPlex,STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.889
Data Source:  STRINGDB
DYNLL1
Tbio
Novelty:  0.00397334
Score:  0.828
Data Source:  STRINGDB
DYNLL2
Tbio
Novelty:  0.11209457
Score:  0.697
Data Source:  STRINGDB
WRNIP1
Tbio
Family:  Enzyme
Novelty:  0.04923448
Score:  0.693
Data Source:  STRINGDB
UBR5
Tbio
Family:  Enzyme
Novelty:  0.00608732
Score:  0.549
Data Source:  STRINGDB
CHEK2
Tchem
Family:  Kinase
Novelty:  0.00068355
Score:  0.538
Data Source:  STRINGDB
CDIP1
Tbio
Family:  TF
Novelty:  0.01727111
Score:  0.52
Data Source:  STRINGDB
EFCAB6
Tdark
Novelty:  0.14872897
Score:  0.514
Data Source:  STRINGDB
Publication Statistics
PubMed Score  20.99

PubMed score by year
PubTator Score  13.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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