Protein Summary
Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.
- ENST00000299575
- ENSP00000299575
- ENSG00000166454
- ENST00000564241
- ENSP00000463478
- ENST00000566488
- ENSP00000455497
- KIAA0431
- ZNF822
- ASCIZ
- ZNF822
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.93 | ||
microRNA | 0.68 | ||
tissue sample | 0.68 | ||
transcription factor perturbation | 0.68 | ||
cell type or tissue | 0.62 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.85 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 122 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.85 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 122 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (20)
WikiPathways (20)
Items per page:
1 – 5 of 20
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
WikiPathways | ATM Signaling Network in Development and Disease | ||||
WikiPathways | ATM Signaling Network in Development and Disease | ||||
WikiPathways | ATM Signaling Network in Development and Disease | ||||
WikiPathways | ATM Signaling Network in Development and Disease | ||||
WikiPathways | miRNA Regulation of DNA Damage Response | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
ATM Signaling Network in Development and Disease | ||||
ATM Signaling Network in Development and Disease | ||||
ATM Signaling Network in Development and Disease | ||||
ATM Signaling Network in Development and Disease | ||||
miRNA Regulation of DNA Damage Response | ||||
Gene Ontology Terms (8)
Functions (3)
Components (1)
Processes (4)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (22)
1 – 10 of 22
CAPN13
Novelty: 0.03153754
p_int: 0.999962502
p_ni: 0.000037498
Score: 0.331
Data Source: BioPlex,STRINGDB
SPECC1L
Novelty: 0.12603151
p_int: 0.980708775
p_ni: 0.019291225
Score: 0.216
Data Source: BioPlex,STRINGDB
ATM
Family: Kinase
Novelty: 0.00023967
Score: 0.889
Data Source: STRINGDB
DYNLL1
Novelty: 0.00134262
Score: 0.828
Data Source: STRINGDB
DYNLL2
Novelty: 0.16487634
Score: 0.697
Data Source: STRINGDB
WRNIP1
Family: Enzyme
Novelty: 0.00257139
Score: 0.693
Data Source: STRINGDB
UBR5
Family: Enzyme
Novelty: 0.00152012
Score: 0.549
Data Source: STRINGDB
CHEK2
Family: Kinase
Novelty: 0.00089751
Score: 0.538
Data Source: STRINGDB
CDIP1
Family: TF
Novelty: 0.02222222
Score: 0.52
Data Source: STRINGDB
EFCAB6
Novelty: 0.15993266
Score: 0.514
Data Source: STRINGDB
Publication Statistics
PubMed Score 22.85
PubMed score by year
PubTator Score 13.58
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MAASEAAAAAGSAALAAGARAVPAATTGAAAAASGPWVPPGPRLRGSRPRPAGATQQPAVPAPPAGELIQ
1-70
PSVSELSRAVRTNILCTVRGCGKILPNSPALNMHLVKSHRLQDGIVNPTIRKDLKTGPKFYCCPIEGCPR
70-140
GPERPFSQFSLVKQHFMKMHAEKKHKCSKCSNSYGTEWDLKRHAEDCGKTFRCTCGCPYASRTALQSHIY
140-210
RTGHEIPAEHRDPPSKKRKMENCAQNQKLSNKTIESLNNQPIPRPDTQELEASEIKLEPSFEDSCGSNTD
210-280
KQTLTTPPRYPQKLLLPKPKVALVKLPVMQFSVMPVFVPTADSSAQPVVLGVDQGSATGAVHLMPLSVGT
280-350
LILGLDSEACSLKESLPLFKIANPIAGEPISTGVQVNFGKSPSNPLQELGNTCQKNSISSINVQTDLSYA
350-420
SQNFIPSAQWATADSSVSSCSQTDLSFDSQVSLPISVHTQTFLPSSKVTSSIAAQTDAFMDTCFQSGGVS
420-490
RETQTSGIESPTDDHVQMDQAGMCGDIFESVHSSYNVATGNIISNSLVAETVTHSLLPQNEPKTLNQDIE
490-560
KSAPIINFSAQNSMLPSQNMTDNQTQTIDLLSDLENILSSNLPAQTLDHRSLLSDTNPGPDTQLPSGPAQ
560-630
NPGIDFDIEEFFSASNIQTQTEESELSTMTTEPVLESLDIETQTDFLLADTSAQSYGCRGNSNFLGLEMF
630-700
DTQTQTDLNFFLDSSPHLPLGSILKHSSFSVSTDSSDTETQTEGVSTAKNIPALESKVQLNSTETQTMSS
700-770
GFETLGSLFFTSNETQTAMDDFLLADLAWNTMESQFSSVETQTSAEPHTVSNF
770-823
MAASEAAAAAGSAALAAGARAVPAATTGAAAAASGPWVPPGPRLRGSRPRPAGATQQPAVPAPPAGELIQPSVSELSRAVRTNILCTVRGCGKILPNSPALNMHLVKSHRLQDGIVNPTIRKDLKTGPKFYCCPIEGCPRGPERPFSQFSLVKQHFMKMHAEKKHKCSKCSNSYGTEWDLKRHAEDCGKTFRCTCGCPYASRTALQSHIYRTGHEIPAEHRDPPSKKRKMENCAQNQKLSNKTIESLNNQPIPRPDTQELEASEIKLEPSFEDSCGSNTDKQTLTTPPRYPQKLLLPKPKVALVKLPVMQFSVMPVFVPTADSSAQPVVLGVDQGSATGAVHLMPLSVGTLILGLDSEACSLKESLPLFKIANPIAGEPISTGVQVNFGKSPSNPLQELGNTCQKNSISSINVQTDLSYASQNFIPSAQWATADSSVSSCSQTDLSFDSQVSLPISVHTQTFLPSSKVTSSIAAQTDAFMDTCFQSGGVSRETQTSGIESPTDDHVQMDQAGMCGDIFESVHSSYNVATGNIISNSLVAETVTHSLLPQNEPKTLNQDIEKSAPIINFSAQNSMLPSQNMTDNQTQTIDLLSDLENILSSNLPAQTLDHRSLLSDTNPGPDTQLPSGPAQNPGIDFDIEEFFSASNIQTQTEESELSTMTTEPVLESLDIETQTDFLLADTSAQSYGCRGNSNFLGLEMFDTQTQTDLNFFLDSSPHLPLGSILKHSSFSVSTDSSDTETQTEGVSTAKNIPALESKVQLNSTETQTMSSGFETLGSLFFTSNETQTAMDDFLLADLAWNTMESQFSSVETQTSAEPHTVSNF
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