Tbio ATMIN ATM interactor

Protein Summary

Description

Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.

Uniprot Accession IDs

• O43313
• A8K4H8
• Q68DC9

Gene Name

• ATMIN

Ensembl ID

• ENST00000299575
• ENSP00000299575
• ENSG00000166454
• ENST00000564241
• ENSP00000463478
• ENST00000566488
• ENSP00000455497

Symbol

• KIAA0431
• ZNF822
• ASCIZ
• ZNF822

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
microRNA	0.68
tissue sample	0.68
transcription factor perturbation	0.68
cell type or tissue	0.62

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.99   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 122   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.99   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (10)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mosaic loss of chromosome Y measurement	EFO_0007783	3	2	3		88.3
glycine measurement	EFO_0009767	4	2	4		86.7
amino acid measurement	EFO_0005134	2	2	2		69.6
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		64.9
protein measurement	EFO_0004747	1	1	1		57.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mosaic loss of chromosome Y measurement	EFO_0007783	3		88.3
glycine measurement	EFO_0009767	4		86.7
amino acid measurement	EFO_0005134	2		69.6
mean corpuscular hemoglobin concentration	EFO_0004528	1		64.9
protein measurement	EFO_0004747	1		57.8

Reset Zoom  Beta Count   Odds Ratio

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ATM interactor	VGNC:13665	738730
Macaque	ATM interactor		717395
Mouse	ATM interactor	MGI:2682328	234776
Dog	ATM interactor	VGNC:53265	100688833
Horse	ATM interactor	VGNC:49420	100069801

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ATM interactor
Macaque	ATM interactor
Mouse	ATM interactor
Dog	ATM interactor
Horse	ATM interactor

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-O43313-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)

WikiPathways (20)

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Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
WikiPathways	ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
WikiPathways	ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
WikiPathways	ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
WikiPathways	miRNA Regulation of DNA Damage Response	454 targets	WP1530_r105862

Name	Explore in Pharos	Explore in Source
ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
miRNA Regulation of DNA Damage Response	454 targets	WP1530_r105862

Gene Ontology Terms (8)

Functions (3)

Components (1)

Processes (4)

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1 – 3 of 3

GO Term	Evidence	Assigned by
dynein complex binding	Inferred from Physical Interaction (IPI)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
transcription regulatory region DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (22)

Explore Interacting Targets

1 – 10 of 22

• See Interactions on String-DB

CAPN13

Tdark

Novelty:  0.27206398

p_int:  0.999962502

p_ni:  0.000037498

Score:  0.331

Data Source:  BioPlex,STRINGDB

SPECC1L

Tbio

Novelty:  0.06116909

p_int:  0.980708775

p_ni:  0.019291225

Score:  0.216

Data Source:  BioPlex,STRINGDB

ATM

Tchem

Family:  Kinase

Novelty:  0.00019169

Score:  0.889

Data Source:  STRINGDB

DYNLL1

Tbio

Novelty:  0.00397334

Score:  0.828

Data Source:  STRINGDB

DYNLL2

Tbio

Novelty:  0.11209457

Score:  0.697

Data Source:  STRINGDB

WRNIP1

Tbio

Family:  Enzyme

Novelty:  0.04923448

Score:  0.693

Data Source:  STRINGDB

UBR5

Tbio

Family:  Enzyme

Novelty:  0.00608732

Score:  0.549

Data Source:  STRINGDB

CHEK2

Tchem

Family:  Kinase

Novelty:  0.00068355

Score:  0.538

Data Source:  STRINGDB

CDIP1

Tbio

Family:  TF

Novelty:  0.01727111

Score:  0.52

Data Source:  STRINGDB

EFCAB6

Tdark

Novelty:  0.14872897

Score:  0.514

Data Source:  STRINGDB

Publication Statistics

PubMed Score  20.99

PubMed score by year

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PubTator Score  13.58

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Activator
Alternative splicing
Complete proteome
DNA damage
Metal-binding
Nucleus
Polymorphism
Reference proteome
Repeat
Transcription

GWAS Trait Find Similar Targets

No Header	No Header
amino acid measurement
blood metabolite measurement
glycine measurement
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean reticulocyte volume
metabolite measurement
mosaic loss of chromosome Y measurement
protein measurement
serum metabolite measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype