Tbio ATMIN ATM interactor

Protein Summary

Description

Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.

Uniprot Accession IDs

• O43313
• A8K4H8
• Q68DC9

Gene Name

• ATMIN

Ensembl ID

• ENST00000299575
• ENSP00000299575
• ENSG00000166454
• ENST00000564241
• ENSP00000463478
• ENST00000566488
• ENSP00000455497

Symbol

• KIAA0431
• ZNF822
• ASCIZ
• ZNF822

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
microRNA	0.68
tissue sample	0.68
transcription factor perturbation	0.68
cell type or tissue	0.62

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.85   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 122   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.85   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (20)

WikiPathways (20)

Items per page:

5

1 – 5 of 20

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
WikiPathways	ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
WikiPathways	ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
WikiPathways	ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
WikiPathways	miRNA Regulation of DNA Damage Response	454 targets	WP1530_r105862

Name	Explore in Pharos	Explore in Source
ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
ATM Signaling Network in Development and Disease	206 targets	WP3878_r105871
miRNA Regulation of DNA Damage Response	454 targets	WP1530_r105862

Gene Ontology Terms (8)

Functions (3)

Components (1)

Processes (4)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
dynein complex binding	Inferred from Physical Interaction (IPI)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
transcription regulatory region DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (22)

Explore Interacting Targets

1 – 10 of 22

• See Interactions on String-DB

CAPN13

Tbio

Novelty: 0.03153754

p_int: 0.999962502

p_ni: 0.000037498

Score: 0.331

Data Source: BioPlex,STRINGDB

SPECC1L

Tbio

Novelty: 0.12603151

p_int: 0.980708775

p_ni: 0.019291225

Score: 0.216

Data Source: BioPlex,STRINGDB

ATM

Tchem

Family: Kinase

Novelty: 0.00023967

Score: 0.889

Data Source: STRINGDB

DYNLL1

Tbio

Novelty: 0.00134262

Score: 0.828

Data Source: STRINGDB

DYNLL2

Tbio

Novelty: 0.16487634

Score: 0.697

Data Source: STRINGDB

WRNIP1

Tbio

Family: Enzyme

Novelty: 0.00257139

Score: 0.693

Data Source: STRINGDB

UBR5

Tbio

Family: Enzyme

Novelty: 0.00152012

Score: 0.549

Data Source: STRINGDB

CHEK2

Tchem

Family: Kinase

Novelty: 0.00089751

Score: 0.538

Data Source: STRINGDB

CDIP1

Tbio

Family: TF

Novelty: 0.02222222

Score: 0.52

Data Source: STRINGDB

EFCAB6

Tdark

Novelty: 0.15993266

Score: 0.514

Data Source: STRINGDB

Publication Statistics

PubMed Score  22.85

PubMed score by year

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PubTator Score  13.58

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MAASEAAAAAGSAALAAGARAVPAATTGAAAAASGPWVPPGPRLRGSRPRPAGATQQPAVPAPPAGELIQ

1-70

PSVSELSRAVRTNILCTVRGCGKILPNSPALNMHLVKSHRLQDGIVNPTIRKDLKTGPKFYCCPIEGCPR

70-140

GPERPFSQFSLVKQHFMKMHAEKKHKCSKCSNSYGTEWDLKRHAEDCGKTFRCTCGCPYASRTALQSHIY

140-210

RTGHEIPAEHRDPPSKKRKMENCAQNQKLSNKTIESLNNQPIPRPDTQELEASEIKLEPSFEDSCGSNTD

210-280

KQTLTTPPRYPQKLLLPKPKVALVKLPVMQFSVMPVFVPTADSSAQPVVLGVDQGSATGAVHLMPLSVGT

280-350

LILGLDSEACSLKESLPLFKIANPIAGEPISTGVQVNFGKSPSNPLQELGNTCQKNSISSINVQTDLSYA

350-420

SQNFIPSAQWATADSSVSSCSQTDLSFDSQVSLPISVHTQTFLPSSKVTSSIAAQTDAFMDTCFQSGGVS

420-490

RETQTSGIESPTDDHVQMDQAGMCGDIFESVHSSYNVATGNIISNSLVAETVTHSLLPQNEPKTLNQDIE

490-560

KSAPIINFSAQNSMLPSQNMTDNQTQTIDLLSDLENILSSNLPAQTLDHRSLLSDTNPGPDTQLPSGPAQ

560-630

NPGIDFDIEEFFSASNIQTQTEESELSTMTTEPVLESLDIETQTDFLLADTSAQSYGCRGNSNFLGLEMF

630-700

DTQTQTDLNFFLDSSPHLPLGSILKHSSFSVSTDSSDTETQTEGVSTAKNIPALESKVQLNSTETQTMSS

700-770

GFETLGSLFFTSNETQTAMDDFLLADLAWNTMESQFSSVETQTSAEPHTVSNF

770-823

MAASEAAAAAGSAALAAGARAVPAATTGAAAAASGPWVPPGPRLRGSRPRPAGATQQPAVPAPPAGELIQPSVSELSRAVRTNILCTVRGCGKILPNSPALNMHLVKSHRLQDGIVNPTIRKDLKTGPKFYCCPIEGCPRGPERPFSQFSLVKQHFMKMHAEKKHKCSKCSNSYGTEWDLKRHAEDCGKTFRCTCGCPYASRTALQSHIYRTGHEIPAEHRDPPSKKRKMENCAQNQKLSNKTIESLNNQPIPRPDTQELEASEIKLEPSFEDSCGSNTDKQTLTTPPRYPQKLLLPKPKVALVKLPVMQFSVMPVFVPTADSSAQPVVLGVDQGSATGAVHLMPLSVGTLILGLDSEACSLKESLPLFKIANPIAGEPISTGVQVNFGKSPSNPLQELGNTCQKNSISSINVQTDLSYASQNFIPSAQWATADSSVSSCSQTDLSFDSQVSLPISVHTQTFLPSSKVTSSIAAQTDAFMDTCFQSGGVSRETQTSGIESPTDDHVQMDQAGMCGDIFESVHSSYNVATGNIISNSLVAETVTHSLLPQNEPKTLNQDIEKSAPIINFSAQNSMLPSQNMTDNQTQTIDLLSDLENILSSNLPAQTLDHRSLLSDTNPGPDTQLPSGPAQNPGIDFDIEEFFSASNIQTQTEESELSTMTTEPVLESLDIETQTDFLLADTSAQSYGCRGNSNFLGLEMFDTQTQTDLNFFLDSSPHLPLGSILKHSSFSVSTDSSDTETQTEGVSTAKNIPALESKVQLNSTETQTMSSGFETLGSLFFTSNETQTAMDDFLLADLAWNTMESQFSSVETQTSAEPHTVSNF

Find similar targets by:

Uniprot Keyword

Activator
Alternative splicing
Complete proteome
DNA damage
Metal-binding
Nucleus
Polymorphism
Reference proteome
Repeat
Transcription