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Tbio
BTAF1
TATA-binding protein-associated factor 172

Protein Summary
Description
Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner. This gene encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II. This TAF has DNA-dependent ATPase activity, which drives the dissociation of TBP from DNA, freeing the TBP to associate with other TATA boxes or TATA-less promoters. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265990
  • ENSP00000265990
  • ENSG00000095564

Symbol
  • TAF172
  • MOT1
  • TAF172
  • TAFII170
  • TAF(II)170
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
protein domain
0.92
interacting protein
0.89
hub protein
0.88
histone modification site profile
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.05   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.05   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
93.6
1
1
0
1.3
78.4
alkaline phosphatase measurement
2
2
1
6.5
70.1
testosterone measurement
2
2
2
62
neutrophil count
2
2
2
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
93.6
0
1.3
78.4
alkaline phosphatase measurement
1
6.5
70.1
testosterone measurement
2
62
neutrophil count
2
56.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
B-TFIID TATA-box binding protein associated factor 1
VGNC:11671
450604
Macaque
B-TFIID TATA-box binding protein associated factor 1
698008
Mouse
MGI:2147538
107182
Rat
RGD:1564130
368042
Dog
B-TFIID TATA-box binding protein associated factor 1
VGNC:38544
100855703
Species
Name
OMA
EggNOG
Inparanoid
Chimp
B-TFIID TATA-box binding protein associated factor 1
Macaque
B-TFIID TATA-box binding protein associated factor 1
Mouse
Rat
Dog
B-TFIID TATA-box binding protein associated factor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14981-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (148)
1 – 10 of 148
SIGLECL1
Tdark
p_int:  0.999914027
p_ni:  0.000085973
Data Source:  BioPlex
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.999895436
p_ni:  0.000104564
Data Source:  BioPlex
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.999621468
p_ni:  0.000378532
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
p_int:  0.998314946
p_ni:  0.001685054
Data Source:  BioPlex
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.995169964
p_ni:  0.004830036
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.980458
p_ni:  0.019542
Data Source:  BioPlex
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.980122548
p_ni:  0.019877452
Data Source:  BioPlex
LPAR4
Tchem
Family:  GPCR
Novelty:  0.02200758
p_int:  0.978930269
p_ni:  0.021069731
Score:  0.164
Data Source:  BioPlex,STRINGDB
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.945774872
p_ni:  0.054225128
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.944024985
p_ni:  0.055975015
Data Source:  BioPlex
Publication Statistics
PubMed Score  71.05

PubMed score by year
PubTator Score  15.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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