You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
NXPH2
Neurexophilin-2

Protein Summary
Description
May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272641
  • ENSP00000272641
  • ENSG00000144227

Symbol
  • NPH2
  • NPH2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
gene perturbation
0.68
trait
0.61
histone modification site profile
0.54
disease
0.5


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.92   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.92   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.999805808
p_ni:  0.000194192
Score:  0.152
Data Source:  BioPlex,STRINGDB
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.997571795
p_ni:  0.002428205
Score:  0.158
Data Source:  BioPlex,STRINGDB
MADD
Tbio
Family:  Enzyme
Novelty:  0.01590443
p_int:  0.997157935
p_ni:  0.002842064
p_wrong:  1e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
FAT4
Tbio
Novelty:  0.01739918
p_int:  0.995797874
p_ni:  0.004202126
Data Source:  BioPlex
PCDH7
Tbio
Novelty:  0.04017185
p_int:  0.978281926
p_ni:  0.021718074
Score:  0.333
Data Source:  BioPlex,STRINGDB
HBA1
Tclin
Novelty:  0.00094113
p_int:  0.949717707
p_ni:  0.049195988
p_wrong:  0.001086304
Data Source:  BioPlex
NRP2
Tbio
Novelty:  0.00764179
p_int:  0.945280178
p_ni:  0.052367715
p_wrong:  0.002352108
Data Source:  BioPlex
TAF7
Tbio
Novelty:  0.05316615
p_int:  0.931079781
p_ni:  0.068920219
p_wrong:  1e-9
Score:  0.227
Data Source:  BioPlex,STRINGDB
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.93107345
p_ni:  0.06892655
Data Source:  BioPlex
CELSR2
Tbio
Family:  GPCR
Novelty:  0.02657319
p_int:  0.914468167
p_ni:  0.085531833
Score:  0.166
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pregnancy induced alloimmunization
1
1
0
2
21.5
self reported educational attainment
1
1
1
0.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pregnancy induced alloimmunization
0
2
21.5
self reported educational attainment
1
0.7
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurexophilin 2
VGNC:14325
742551
Macaque
neurexophilin 2
704413
Mouse
MGI:107491
18232
Rat
RGD:1598138
679932
Dog
neurexophilin 2
VGNC:44078
102154650
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurexophilin 2
Macaque
neurexophilin 2
Mouse
Rat
Dog
neurexophilin 2
Publication Statistics
PubMed Score 1.92
PubMed score by year
PubTator Score 33.21
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title