Tdark NXPH2 Neurexophilin-2

Protein Summary

Description

May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

Uniprot Accession IDs

• O95156
• B7WP24
• Q494R1
• Q75QC3

Gene Name

• NXPH2

Ensembl ID

• ENST00000272641
• ENSP00000272641
• ENSG00000144227

Symbol

• NPH2
• NPH2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.83
gene perturbation	0.68
trait	0.61
histone modification site profile	0.54
disease	0.5

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Neurexophilin-2

DTO Classes

Protein / Signaling / Neurexophilin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.92   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.92   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (49)

Explore Interacting Targets

1 – 10 of 49

• See Interactions on String-DB

EEF1A2

Tchem

Novelty:  0.001472

p_int:  0.999805808

p_ni:  0.000194192

Score:  0.152

Data Source:  BioPlex,STRINGDB

ADGRV1

Tbio

Family:  GPCR

Novelty:  0.01398129

p_int:  0.997571795

p_ni:  0.002428205

Score:  0.158

Data Source:  BioPlex,STRINGDB

MADD

Tbio

Family:  Enzyme

Novelty:  0.01590443

p_int:  0.997157935

p_ni:  0.002842064

p_wrong:  1e-9

Score:  0.179

Data Source:  BioPlex,STRINGDB

FAT4

Tbio

Novelty:  0.01739918

p_int:  0.995797874

p_ni:  0.004202126

Data Source:  BioPlex

PCDH7

Tbio

Novelty:  0.04017185

p_int:  0.978281926

p_ni:  0.021718074

Score:  0.333

Data Source:  BioPlex,STRINGDB

HBA1

Tclin

Novelty:  0.00094113

p_int:  0.949717707

p_ni:  0.049195988

p_wrong:  0.001086304

Data Source:  BioPlex

NRP2

Tbio

Novelty:  0.00764179

p_int:  0.945280178

p_ni:  0.052367715

p_wrong:  0.002352108

Data Source:  BioPlex

TAF7

Tbio

Novelty:  0.05316615

p_int:  0.931079781

p_ni:  0.068920219

p_wrong:  1e-9

Score:  0.227

Data Source:  BioPlex,STRINGDB

UBR1

Tbio

Family:  Enzyme

Novelty:  0.00998888

p_int:  0.93107345

p_ni:  0.06892655

Data Source:  BioPlex

CELSR2

Tbio

Family:  GPCR

Novelty:  0.02657319

p_int:  0.914468167

p_ni:  0.085531833

Score:  0.166

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (1)

Components (1)

Processes (1)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
signaling receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
pregnancy induced alloimmunization	EFO_0008462	1	1	0	2	21.5
self reported educational attainment	EFO_0004784	1	1	1		0.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
pregnancy induced alloimmunization	EFO_0008462	0	2	21.5
self reported educational attainment	EFO_0004784	1		0.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

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Complete proteome
Glycoprotein
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
pregnancy induced alloimmunization
self reported educational attainment

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	neurexophilin 2	VGNC:14325	742551
Macaque	neurexophilin 2		704413
Mouse	neurexophilin 2	MGI:107491	18232
Rat	neurexophilin 2	RGD:1598138	679932
Dog	neurexophilin 2	VGNC:44078	102154650

Species	Name	OMA	EggNOG	Inparanoid
Chimp	neurexophilin 2
Macaque	neurexophilin 2
Mouse	neurexophilin 2
Rat	neurexophilin 2
Dog	neurexophilin 2

Publication Statistics

PubMed Score 1.92

PubMed score by year

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PubTator Score 33.21

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title