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Tdark
NWD1
NACHT domain- and WD repeat-containing protein 1

Protein Summary
Description
May play a role in the control of androgen receptor (AR) protein steady-state levels. The protein encoded by this gene is thought to be a cytosolic protein and predicted to contain a NACHT domain and multiple WD40 repeats. Increased expression of this gene was observed in some prostate cancer cell lines. Knocking down expression of this gene results in decreased androgen receptor protein levels, indicating that this gene may be important in modulating androgen receptor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379808
  • ENSP00000369136
  • ENSG00000188039
  • ENST00000438489
  • ENSP00000400248
  • ENST00000524140
  • ENSP00000428579
  • ENST00000552788
  • ENSP00000447224
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
molecular function
0.73
microRNA
0.67
tissue sample
0.65
transcription factor
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.75   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 6   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.75   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (120)
PRPF6
Tbio
Novelty:  0.02818008
Score:  0.917
Data Source:  STRINGDB
PRPF3
Tbio
Novelty:  0.01600014
Score:  0.901
Data Source:  STRINGDB
BCAS2
Tbio
Novelty:  0.05425016
Score:  0.891
Data Source:  STRINGDB
SMU1
Tbio
Novelty:  0.02232467
Score:  0.89
Data Source:  STRINGDB
SNRPD3
Tbio
Novelty:  0.02022419
Score:  0.888
Data Source:  STRINGDB
SNU13
Tbio
Novelty:  0.01613497
Score:  0.887
Data Source:  STRINGDB
CRNKL1
Tbio
Novelty:  0.10274174
Score:  0.885
Data Source:  STRINGDB
LSM2
Tbio
Novelty:  0.03339237
Score:  0.88
Data Source:  STRINGDB
SF3B5
Tdark
Novelty:  0.26636354
Score:  0.88
Data Source:  STRINGDB
LSM8
Tbio
Novelty:  0.08782322
Score:  0.878
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
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GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NACHT and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:27619]
Mouse
MGI:2442268
319555
Dog
NACHT and WD repeat domain containing 1
VGNC:44069
476678
Horse
NACHT and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:27619]
Cow
NACHT and WD repeat domain containing 1
VGNC:32373
537999
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NACHT and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:27619]
Mouse
Dog
NACHT and WD repeat domain containing 1
Horse
NACHT and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:27619]
Cow
NACHT and WD repeat domain containing 1
Publication Statistics
PubMed Score 6.75
PubMed score by year
PubTator Score 1.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title