Tdark NHSL2 NHS-like protein 2

Protein Summary

Uniprot Accession IDs

• Q5HYW2
• B2RN94

Gene Name

• NHSL2

Ensembl ID

• ENST00000510661
• ENSP00000424079
• ENSG00000204131

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.68
tissue sample	0.66
cell type or tissue	0.62
histone modification site profile	0.62
chemical	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.13   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 14   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.13   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (34)

Explore Interacting Targets

1 – 10 of 34

• See Interactions on String-DB

BRK1

Tbio

Novelty:  0.02289534

p_int:  0.999996903

p_ni:  0.000003075

p_wrong:  2.3e-8

Score:  0.426

Data Source:  BioPlex,STRINGDB

FGFR1OP2

Tbio

Novelty:  0.1082136

p_int:  0.999842325

p_ni:  0.000148962

p_wrong:  0.000008713

Score:  0.165

Data Source:  BioPlex,STRINGDB

ABI2

Tbio

Novelty:  0.02324355

p_int:  0.999826629

p_ni:  0.000173371

Score:  0.632

Data Source:  BioPlex,STRINGDB

WASF1

Tbio

Novelty:  0.00977488

p_int:  0.999705866

p_ni:  0.00029304

p_wrong:  0.000001094

Score:  0.663

Data Source:  BioPlex,STRINGDB

NCK1

Tbio

Novelty:  0.00352084

p_int:  0.999705227

p_ni:  0.000294713

p_wrong:  6e-8

Data Source:  BioPlex

ABI1

Tbio

Novelty:  0.00796638

p_int:  0.999274579

p_ni:  0.000725358

p_wrong:  6.3e-8

Score:  0.633

Data Source:  BioPlex,STRINGDB

NCKAP1

Tbio

Novelty:  0.03486454

p_int:  0.998977769

p_ni:  0.001022232

Score:  0.676

Data Source:  BioPlex,STRINGDB

CYFIP2

Tbio

Novelty:  0.01910939

p_int:  0.998577212

p_ni:  0.001422788

Score:  0.799

Data Source:  BioPlex,STRINGDB

WASF2

Tbio

Novelty:  0.00968798

p_int:  0.99839334

p_ni:  0.001606658

p_wrong:  2e-9

Score:  0.708

Data Source:  BioPlex,STRINGDB

SLMAP

Tbio

Novelty:  0.03974856

p_int:  0.998227778

p_ni:  0.001772222

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (1)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
cell differentiation	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	2	2	2		54.3
platelet crit	EFO_0007985	1	1	1		35
platelet count	EFO_0004309	1	1	1		30.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	2		54.3
platelet crit	EFO_0007985	1		35
platelet count	EFO_0004309	1		30.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

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Complete proteome
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
platelet count
platelet crit
testosterone measurement

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	NHS-like 2	MGI:3645090	100042480
Dog	NHS like 2	VGNC:43806	491954
Cow	NHS like 2	VGNC:32073	513680
Anole lizard	NHS like 2 [Source:HGNC Symbol;Acc:HGNC:33737]

Species	Name	OMA	EggNOG	Inparanoid
Mouse	NHS-like 2
Dog	NHS like 2
Cow	NHS like 2
Anole lizard	NHS like 2 [Source:HGNC Symbol;Acc:HGNC:33737]

Publication Statistics

PubMed Score 0.13

PubMed score by year

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PubTator Score 0.20

PubTator score by year

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Related Publications

Text Mined References (3)

Items per page:

10

0 of 0

PMID	Year	Title