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Tdark
NHSL2
NHS-like protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000510661
  • ENSP00000424079
  • ENSG00000204131
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
tissue sample
0.66
cell type or tissue
0.62
histone modification site profile
0.62
chemical
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.13   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.13   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999996903
p_ni:  0.000003075
p_wrong:  2.3e-8
Score:  0.426
Data Source:  BioPlex,STRINGDB
FGFR1OP2
Tbio
Novelty:  0.1082136
p_int:  0.999842325
p_ni:  0.000148962
p_wrong:  0.000008713
Score:  0.165
Data Source:  BioPlex,STRINGDB
ABI2
Tbio
Novelty:  0.02324355
p_int:  0.999826629
p_ni:  0.000173371
Score:  0.632
Data Source:  BioPlex,STRINGDB
WASF1
Tbio
Novelty:  0.00977488
p_int:  0.999705866
p_ni:  0.00029304
p_wrong:  0.000001094
Score:  0.663
Data Source:  BioPlex,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.999705227
p_ni:  0.000294713
p_wrong:  6e-8
Data Source:  BioPlex
ABI1
Tbio
Novelty:  0.00796638
p_int:  0.999274579
p_ni:  0.000725358
p_wrong:  6.3e-8
Score:  0.633
Data Source:  BioPlex,STRINGDB
NCKAP1
Tbio
Novelty:  0.03486454
p_int:  0.998977769
p_ni:  0.001022232
Score:  0.676
Data Source:  BioPlex,STRINGDB
CYFIP2
Tbio
Novelty:  0.01910939
p_int:  0.998577212
p_ni:  0.001422788
Score:  0.799
Data Source:  BioPlex,STRINGDB
WASF2
Tbio
Novelty:  0.00968798
p_int:  0.99839334
p_ni:  0.001606658
p_wrong:  2e-9
Score:  0.708
Data Source:  BioPlex,STRINGDB
SLMAP
Tbio
Novelty:  0.03974856
p_int:  0.998227778
p_ni:  0.001772222
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
54.3
platelet crit
1
1
1
35
platelet count
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
54.3
platelet crit
1
35
platelet count
1
30.2
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3645090
100042480
Dog
NHS like 2
VGNC:43806
491954
Cow
NHS like 2
VGNC:32073
513680
Anole lizard
NHS like 2 [Source:HGNC Symbol;Acc:HGNC:33737]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
NHS like 2
Cow
NHS like 2
Anole lizard
NHS like 2 [Source:HGNC Symbol;Acc:HGNC:33737]
Publication Statistics
PubMed Score 0.13
PubMed score by year
PubTator Score 0.20
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title