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Tbio
N4BP2L2
NEDD4-binding protein 2-like 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267068
  • ENSP00000267068
  • ENSG00000244754
  • ENST00000399396
  • ENSP00000382328
  • ENST00000446957
  • ENSP00000394239

Symbol
  • CG005
  • PFAAP5
  • CG005
  • CG016
  • PFAAP5
  • 92M18.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.74
gene perturbation
0.69
histone modification site profile
0.68
tissue sample
0.68
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.98   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.98   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
PRPF4
Tchem
Novelty:  0.08229072
p_int:  0.99955561
p_ni:  0.00044439
Data Source:  BioPlex
PRG2
Tbio
Novelty:  0.00548995
p_int:  0.992815306
p_ni:  0.007184693
Data Source:  BioPlex
MRPS18C
Tdark
Novelty:  0.42868428
p_int:  0.992128455
p_ni:  0.007871515
p_wrong:  3e-8
Data Source:  BioPlex
WNT4
Tbio
Novelty:  0.00276803
p_int:  0.976870109
p_ni:  0.023129862
p_wrong:  2.9e-8
Data Source:  BioPlex
LOX
Tchem
Family:  Enzyme
Novelty:  0.000273
p_int:  0.976493928
p_ni:  0.023502931
p_wrong:  0.000003141
Data Source:  BioPlex
IQCN
Tdark
Novelty:  2.74045479
p_int:  0.969905567
p_ni:  0.030094433
Data Source:  BioPlex
SIRT6
Tchem
Family:  Epigenetic
Novelty:  0.00155366
p_int:  0.960484308
p_ni:  0.039515692
Data Source:  BioPlex
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.954419974
p_ni:  0.045558519
p_wrong:  0.000021507
Data Source:  BioPlex
PIP
Tbio
Novelty:  0.00208509
p_int:  0.944332342
p_ni:  0.055666251
p_wrong:  0.000001407
Data Source:  BioPlex
TMPRSS5
Tbio
Family:  Enzyme
Novelty:  0.23903784
p_int:  0.896562502
p_ni:  0.10168708
p_wrong:  0.001750418
Score:  0.297
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
8
8
97.2
low density lipoprotein cholesterol measurement
6
7
10
94.3
mean platelet volume
3
3
3
93.5
total cholesterol measurement
2
4
4
91.7
body mass index
4
2
4
87
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
8
97.2
low density lipoprotein cholesterol measurement
10
94.3
mean platelet volume
3
93.5
total cholesterol measurement
4
91.7
body mass index
4
87
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NEDD4 binding protein 2 like 2
VGNC:51847
452528
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NEDD4 binding protein 2 like 2
Publication Statistics
PubMed Score 3.98
PubMed score by year
PubTator Score 1.13
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title