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Tdark
MTX3
Metaxin-3

Protein Summary
Description
Could function in transport of proteins into the mitochondrion.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000509852
  • ENSP00000423302
  • ENSG00000177034
  • ENST00000512528
  • ENSP00000424798
  • ENST00000512560
  • ENSP00000423600
  • ENST00000617335
  • ENSP00000484157
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
cell type or tissue
0.86
microRNA
0.74
cellular component
0.67
tissue sample
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.05   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 37   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.05   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
MTX2
Tbio
Novelty:  0.02047483
p_int:  0.999988192
p_ni:  0.000011808
Score:  0.744
Data Source:  BioPlex,STRINGDB
TRAK1
Tbio
Novelty:  0.03561577
p_int:  0.999376585
p_ni:  0.000623415
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.99525943
p_ni:  0.004740567
p_wrong:  3e-9
Data Source:  BioPlex
CD244
Tbio
Novelty:  0.01137579
p_int:  0.989851933
p_ni:  0.010148066
Data Source:  BioPlex
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
p_int:  0.989851322
p_ni:  0.010148677
p_wrong:  1e-9
Data Source:  BioPlex
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
p_int:  0.985317984
p_ni:  0.014682016
Data Source:  BioPlex
CD68
Tbio
Novelty:  0.00017859
p_int:  0.984945184
p_ni:  0.015054815
Score:  0.201
Data Source:  BioPlex,STRINGDB
CMTM8
Tbio
Novelty:  0.0953768
p_int:  0.984220482
p_ni:  0.015775463
p_wrong:  0.000004055
Data Source:  BioPlex
TMEM171
Tdark
Novelty:  2.00247773
p_int:  0.983908394
p_ni:  0.016091606
Data Source:  BioPlex
SLC5A8
Tchem
Family:  Transporter
Novelty:  0.00892277
p_int:  0.975218194
p_ni:  0.024781806
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
2
1
2
84.3
corneal resistance factor
1
1
1
74.9
intraocular pressure measurement
1
2
2
67.9
educational attainment
1
1
1
53.6
substance abuse
1
1
1
50.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
2
84.3
corneal resistance factor
1
74.9
intraocular pressure measurement
2
67.9
educational attainment
1
53.6
substance abuse
1
50.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2686040
382793
Rat
RGD:1583002
688905
Dog
metaxin 3
VGNC:53189
488931
Horse
metaxin 3 [Source:HGNC Symbol;Acc:HGNC:24812]
Cow
metaxin 3
616872
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
metaxin 3
Horse
metaxin 3 [Source:HGNC Symbol;Acc:HGNC:24812]
Cow
metaxin 3
Publication Statistics
PubMed Score 34.05
PubMed score by year
PubTator Score 15.78
PubTator score by year
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Related Publications
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PMID
Year
Title