MRAP2
Melanocortin-2 receptor accessory protein 2
Protein Summary
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo. This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016]
- ENST00000257776
- ENSP00000257776
- ENSG00000135324
- C6orf117
- C6orf117
- bA51G5.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.76 | ||
cell line | 0.6 | ||
histone modification site profile | 0.59 | ||
transcription factor | 0.52 | ||
biological process | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.15 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 102 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.15 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 102 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (94)
SLC25A51
Family: Transporter
Novelty: 0.21568087
p_int: 0.999995577
p_ni: 0.000004422
p_wrong: 1e-9
Data Source: BioPlex
TEX2
Novelty: 0.07679544
p_int: 0.999988792
p_ni: 0.000011204
p_wrong: 4e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
FGFR4
Family: Kinase
Novelty: 0.00258329
p_int: 0.99996634
p_ni: 0.000028737
p_wrong: 0.000004924
Data Source: BioPlex
BMPR2
Family: Kinase
Novelty: 0.00155912
p_int: 0.999855762
p_ni: 0.000125433
p_wrong: 0.000018805
Data Source: BioPlex
CC2D1A
Novelty: 0.01970021
p_int: 0.99979664
p_ni: 0.000200173
p_wrong: 0.000003186
Data Source: BioPlex
UGCG
Family: Enzyme
Novelty: 0.00481791
p_int: 0.999624967
p_ni: 0.000375022
p_wrong: 1.1e-8
Data Source: BioPlex
WDR41
Novelty: 0.20400077
p_int: 0.998390303
p_ni: 0.001543891
p_wrong: 0.000065806
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (7)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | melanocortin 2 receptor accessory protein 2 | VGNC:3489 | 463208 | |||||
Mouse | MGI:3609239 | 244958 | ||||||
Rat | RGD:1309873 | 363112 | ||||||
Dog | melanocortin 2 receptor accessory protein 2 | VGNC:43357 | 611524 | |||||
Horse | melanocortin 2 receptor accessory protein 2 | VGNC:20306 | 100065482 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | melanocortin 2 receptor accessory protein 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | melanocortin 2 receptor accessory protein 2 | |||||
Horse | melanocortin 2 receptor accessory protein 2 | |||||
Publication Statistics
PubMed Score 28.15
PubMed score by year
PubTator Score 12.56
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (12)
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