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Tbio
MRAP2
Melanocortin-2 receptor accessory protein 2

Protein Summary
Description
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo. This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257776
  • ENSP00000257776
  • ENSG00000135324

Symbol
  • C6orf117
  • C6orf117
  • bA51G5.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
cell line
0.6
histone modification site profile
0.59
transcription factor
0.52
biological process
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.15   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.15   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
SLC25A51
Tbio
Family:  Transporter
Novelty:  0.21568087
p_int:  0.999995577
p_ni:  0.000004422
p_wrong:  1e-9
Data Source:  BioPlex
TEX2
Tbio
Novelty:  0.07679544
p_int:  0.999988792
p_ni:  0.000011204
p_wrong:  4e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
PODXL
Tbio
Novelty:  0.00306913
p_int:  0.999988454
p_ni:  0.000011546
Data Source:  BioPlex
UST
Tbio
Family:  Enzyme
Novelty:  0.03897672
p_int:  0.999983799
p_ni:  0.000016201
Data Source:  BioPlex
FGFR4
Tclin
Family:  Kinase
Novelty:  0.00258329
p_int:  0.99996634
p_ni:  0.000028737
p_wrong:  0.000004924
Data Source:  BioPlex
BMPR2
Tchem
Family:  Kinase
Novelty:  0.00155912
p_int:  0.999855762
p_ni:  0.000125433
p_wrong:  0.000018805
Data Source:  BioPlex
CC2D1A
Tbio
Novelty:  0.01970021
p_int:  0.99979664
p_ni:  0.000200173
p_wrong:  0.000003186
Data Source:  BioPlex
UGCG
Tclin
Family:  Enzyme
Novelty:  0.00481791
p_int:  0.999624967
p_ni:  0.000375022
p_wrong:  1.1e-8
Data Source:  BioPlex
LRP12
Tbio
Novelty:  0.11426952
p_int:  0.99861052
p_ni:  0.00138947
p_wrong:  1e-8
Data Source:  BioPlex
WDR41
Tbio
Novelty:  0.20400077
p_int:  0.998390303
p_ni:  0.001543891
p_wrong:  0.000065806
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
melanocortin 2 receptor accessory protein 2
VGNC:3489
463208
Mouse
MGI:3609239
244958
Rat
RGD:1309873
363112
Dog
melanocortin 2 receptor accessory protein 2
VGNC:43357
611524
Horse
melanocortin 2 receptor accessory protein 2
VGNC:20306
100065482
Species
Name
OMA
EggNOG
Inparanoid
Chimp
melanocortin 2 receptor accessory protein 2
Mouse
Rat
Dog
melanocortin 2 receptor accessory protein 2
Horse
melanocortin 2 receptor accessory protein 2
Publication Statistics
PubMed Score 28.15
PubMed score by year
PubTator Score 12.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title