Tdark LYZL2 Lysozyme-like protein 2

Protein Summary

Description

Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL2 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]

Uniprot Accession IDs

• Q7Z4W2
• Q6NZ69
• Lysozyme-2

Gene Name

• LYZL2

Ensembl ID

• ENST00000375318
• ENSP00000364467
• ENSG00000151033
• ENST00000647634
• ENSP00000497408

Symbol

• LYZD2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
metabolite	0.45
phenotype	0.36
disease	0.35
biological term	0.33

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.41   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 41   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.41   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (66)

Explore Interacting Targets

1 – 10 of 66

• See Interactions on String-DB

GALNT18

Tbio

Family:  Enzyme

Novelty:  0.15496205

p_int:  0.999921102

p_ni:  0.000078897

p_wrong:  1e-9

Data Source:  BioPlex

ENTPD5

Tbio

Family:  Enzyme

Novelty:  0.01714402

p_int:  0.99985106

p_ni:  0.000037241

p_wrong:  0.0001117

Score:  0.179

Data Source:  BioPlex,STRINGDB

LOXL2

Tchem

Family:  Enzyme

Novelty:  0.00599536

p_int:  0.999467121

p_ni:  0.000532867

p_wrong:  1.2e-8

Data Source:  BioPlex

B4GALNT4

Tdark

Family:  Enzyme

Novelty:  0.19278471

p_int:  0.998772617

p_ni:  0.000704747

p_wrong:  0.000522636

Data Source:  BioPlex

COL6A2

Tbio

Novelty:  0.01275082

p_int:  0.99838354

p_ni:  0.00161646

Data Source:  BioPlex

FKBP14

Tbio

Family:  Enzyme

Novelty:  0.02742616

p_int:  0.998146972

p_ni:  0.001822831

p_wrong:  0.000030197

Data Source:  BioPlex

SULF1

Tbio

Family:  Enzyme

Novelty:  0.00992209

p_int:  0.998016449

p_ni:  0.001506995

p_wrong:  0.000476556

Data Source:  BioPlex

VWDE

Tdark

Novelty:  0.37298162

p_int:  0.997705708

p_ni:  0.002283438

p_wrong:  0.000010854

Data Source:  BioPlex

PCYOX1L

Tdark

Family:  Enzyme

Novelty:  1.25398886

p_int:  0.997588425

p_ni:  0.002411556

p_wrong:  1.8e-8

Data Source:  BioPlex

TMEM67

Tbio

Novelty:  0.02573267

p_int:  0.997337728

p_ni:  0.002661085

p_wrong:  0.000001187

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (1)

Components (1)

Processes (3)

Find Similar Targets

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
lysozyme activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	1	1	1		26.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	1		26.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Glycosidase
Hydrolase
Polymorphism
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

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mathematical ability

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	lysozyme-like 1	MGI:1914578	67328
Rat	lysozyme-like 1	RGD:1559869	364745
Dog	lysozyme-like protein 1		487083
Horse	lysozyme-like protein 1		100055156
Cow	lysozyme-like 1		512087

Species	Name	OMA	EggNOG	Inparanoid
Mouse	lysozyme-like 1
Rat	lysozyme-like 1
Dog	lysozyme-like protein 1
Horse	lysozyme-like protein 1
Cow	lysozyme-like 1

Publication Statistics

PubMed Score 1.41

PubMed score by year

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PubTator Score 1.83

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title