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Tdark
LRRC17
Leucine-rich repeat-containing protein 17

Protein Summary
Description
Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249377
  • ENSP00000249377
  • ENSG00000128606
  • ENST00000339431
  • ENSP00000344242

Symbol
  • P37NB
  • P37NB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
gene perturbation
0.61
small molecule perturbation
0.57
cell type or tissue
0.53
PubMedID
0.52


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
GAS2L3
Tbio
Novelty:  0.12695768
Score:  0.725
Data Source:  STRINGDB
SESTD1
Tbio
Novelty:  0.2052002
Score:  0.698
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.685
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.685
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.685
Data Source:  STRINGDB
ARHGEF39
Tbio
Novelty:  0.30447134
Score:  0.667
Data Source:  STRINGDB
MYBPH
Tbio
Novelty:  0.00247863
Score:  0.656
Data Source:  STRINGDB
DACT1
Tbio
Novelty:  0.00217915
Score:  0.655
Data Source:  STRINGDB
G2E3
Tbio
Family:  Epigenetic
Novelty:  0.18174499
Score:  0.634
Data Source:  STRINGDB
CAVIN4
Tbio
Novelty:  0.03177065
Score:  0.623
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
5
3
1.1
94.8
1
1
0
10.7
51.2
mental or behavioural disorder
1
1
0
10.7
51.2
type 2 diabetes mellitus
1
1
0
1.1
35
cortical surface area measurement
1
1
0
6.3
30.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
1.1
94.8
0
10.7
51.2
mental or behavioural disorder
0
10.7
51.2
type 2 diabetes mellitus
0
1.1
35
cortical surface area measurement
0
6.3
30.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 17
VGNC:14039
742770
Macaque
leucine rich repeat containing 17
695422
Mouse
MGI:1921761
74511
Rat
RGD:1560165
502715
Dog
leucine rich repeat containing 17
VGNC:51879
100685094
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 17
Macaque
leucine rich repeat containing 17
Mouse
Rat
Dog
leucine rich repeat containing 17
Publication Statistics
PubMed Score 7.68
PubMed score by year
PubTator Score 3.44
PubTator score by year
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Related Publications
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PMID
Year
Title