You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LRP12
Low-density lipoprotein receptor-related protein 12

Protein Summary
Description
Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor. This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276654
  • ENSP00000276654
  • ENSG00000147650
  • ENST00000424843
  • ENSP00000399148

Symbol
  • ST7
  • ST7
  • MIG13A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
transcription factor perturbation
0.8
transcription factor binding site profile
0.7
small molecule perturbation
0.6
cell line
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.7   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.7   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
MRAP2
Tbio
Novelty:  0.0420503
p_int:  0.99861052
p_ni:  0.00138947
p_wrong:  1e-8
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.998269016
p_ni:  0.00172841
p_wrong:  0.000002574
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.998010847
p_ni:  0.001989001
p_wrong:  1.52e-7
Data Source:  BioPlex
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
p_int:  0.995775642
p_ni:  0.004223886
p_wrong:  4.72e-7
Data Source:  BioPlex
TMED6
Tdark
Novelty:  0.598611
p_int:  0.995702563
p_ni:  0.00429698
p_wrong:  4.57e-7
Data Source:  BioPlex
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.995657567
p_ni:  0.004342173
p_wrong:  2.6e-7
Data Source:  BioPlex
PSG1
Tbio
Novelty:  0.0239046
p_int:  0.995652235
p_ni:  0.0043475
p_wrong:  2.65e-7
Data Source:  BioPlex
IL17RC
Tclin
Novelty:  0.01844832
p_int:  0.991370954
p_ni:  0.008628923
p_wrong:  1.23e-7
Data Source:  BioPlex
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.987605036
p_ni:  0.012394877
p_wrong:  8.8e-8
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.985557226
p_ni:  0.014433395
p_wrong:  0.000009379
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Metabolism
Reactome
Metabolism of fat-soluble vitamins
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Metabolism
Metabolism of fat-soluble vitamins
Metabolism of vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
salivary metabolite measurement
1
1
1
84.6
testosterone measurement
1
1
1
80.4
metabolite measurement
1
1
1
77.7
2
2
2
60.8
irritability measurement
1
2
0
5.5
21.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
salivary metabolite measurement
1
84.6
testosterone measurement
1
80.4
metabolite measurement
1
77.7
2
60.8
irritability measurement
0
5.5
21.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
LDL receptor related protein 12
695448
Mouse
MGI:2443132
239393
Rat
RGD:1304943
314941
Horse
LDL receptor related protein 12
VGNC:19760
100062962
Cow
LDL receptor related protein 12
VGNC:30989
519993
Species
Name
OMA
EggNOG
Inparanoid
Macaque
LDL receptor related protein 12
Mouse
Rat
Horse
LDL receptor related protein 12
Cow
LDL receptor related protein 12
Publication Statistics
PubMed Score 9.70
PubMed score by year
PubTator Score 5.58
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title