You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
GTPBP8
GTP-binding protein 8

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295864
  • ENSP00000295864
  • ENSG00000163607
  • ENST00000383677
  • ENSP00000373175
  • ENST00000383678
  • ENSP00000373176
  • ENST00000485330
  • ENSP00000418877

Symbol
  • HSPC135
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
molecular function
0.79
cell type or tissue
0.74
histone modification site profile
0.71
tissue
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.6   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.6   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.999997734
p_ni:  0.000002266
Score:  0.31
Data Source:  BioPlex,STRINGDB
AMIGO3
Tdark
Novelty:  7.6744186
p_int:  0.999992525
p_ni:  0.000007412
p_wrong:  6.3e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
NIT1
Tbio
Family:  Enzyme
Novelty:  0.00498587
p_int:  0.999858587
p_ni:  0.000141412
p_wrong:  1e-9
Data Source:  BioPlex
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.999810172
p_ni:  0.000189828
Score:  0.155
Data Source:  BioPlex,STRINGDB
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.999791869
p_ni:  0.000208131
Data Source:  BioPlex
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.999717437
p_ni:  0.000282562
Score:  0.388
Data Source:  BioPlex,STRINGDB
MRPS25
Tdark
Novelty:  0.59354314
p_int:  0.997651724
p_ni:  0.001646843
p_wrong:  0.000701432
Data Source:  BioPlex
MRPL21
Tdark
Novelty:  0.56552559
p_int:  0.997399878
p_ni:  0.002598534
p_wrong:  0.000001588
Score:  0.341
Data Source:  BioPlex,STRINGDB
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.988842764
p_ni:  0.001572476
p_wrong:  0.00958476
Score:  0.163
Data Source:  BioPlex,STRINGDB
COQ5
Tbio
Family:  Enzyme
Novelty:  0.04664953
p_int:  0.936284603
p_ni:  0.021817555
p_wrong:  0.041897842
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
77.1
eosinophil percentage of leukocytes
1
1
1
65.5
sum of eosinophil and basophil counts
1
1
1
30.9
asthma
1
1
0
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
77.1
eosinophil percentage of leukocytes
1
65.5
sum of eosinophil and basophil counts
1
30.9
asthma
0
1
30.2
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GTP binding protein 8 (putative)
VGNC:9680
743648
Macaque
GTP binding protein 8 (putative)
708820
Mouse
MGI:1913317
66067
Rat
RGD:1310025
360714
Dog
GTP binding protein 8 (putative)
VGNC:53074
607600
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GTP binding protein 8 (putative)
Macaque
GTP binding protein 8 (putative)
Mouse
Rat
Dog
GTP binding protein 8 (putative)
Publication Statistics
PubMed Score 0.60
PubMed score by year
PubTator Score 0.03
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title