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Tbio
GREB1
Protein GREB1

Protein Summary
Description
May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers. This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234142
  • ENSP00000234142
  • ENSG00000196208
  • ENST00000263834
  • ENSP00000263834
  • ENST00000381483
  • ENSP00000370892
  • ENST00000381486
  • ENSP00000370896
  • ENST00000396123
  • ENSP00000379429

Symbol
  • KIAA0575
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.85
gene perturbation
0.76
transcription factor
0.7
microRNA
0.63
small molecule perturbation
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.34   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.34   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
p_int:  0.999633708
p_ni:  0.000366292
Score:  0.187
Data Source:  BioPlex,STRINGDB
DPPA3
Tbio
Novelty:  0.03361743
p_int:  0.998535195
p_ni:  0.001463988
p_wrong:  8.17e-7
Data Source:  BioPlex
DNAJC7
Tbio
Novelty:  0.02133191
p_int:  0.997539863
p_ni:  0.002446575
p_wrong:  0.000013561
Score:  0.188
Data Source:  BioPlex,STRINGDB
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.997245533
p_ni:  0.000225994
p_wrong:  0.002528473
Data Source:  BioPlex
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.98
Data Source:  Reactome,STRINGDB
NCOA3
Tchem
Family:  Epigenetic
Novelty:  0.00193529
Score:  0.953
Data Source:  STRINGDB
NR5A2
Tchem
Family:  NR
Novelty:  0.00349812
Score:  0.945
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.933
Data Source:  Reactome,STRINGDB
ZNF217
Tbio
Family:  TF
Novelty:  0.01313576
Score:  0.923
Data Source:  STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.91
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Estrogen-dependent gene expression
Signal Transduction
Signaling by Nuclear Receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
2
3
87.8
2
3
0
1.1
84.3
sex hormone-binding globulin measurement
2
1
2
57.8
1
2
0
1.2
50.6
electrocardiography
1
1
3
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
87.8
0
1.1
84.3
sex hormone-binding globulin measurement
2
57.8
0
1.2
50.6
electrocardiography
3
45.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth regulating estrogen receptor binding 1
VGNC:261
459034
Macaque
growth regulation by estrogen in breast cancer 1
697434
Mouse
MGI:2149712
268527
Rat
RGD:1564091
500633
Dog
growth regulating estrogen receptor binding 1
VGNC:53638
610007
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth regulating estrogen receptor binding 1
Macaque
growth regulation by estrogen in breast cancer 1
Mouse
Rat
Dog
growth regulating estrogen receptor binding 1
Publication Statistics
PubMed Score 56.34
PubMed score by year
PubTator Score 37.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title