Tbio GPN3 GPN-loop GTPase 3

Protein Summary

Description

Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

Uniprot Accession IDs

• Q9UHW5
• B2RC54
• D4YWV1
• F5H759
• Q53FS3
• Q6UVZ6
• Q7Z3D3
• Q8NEI2
• Q96HK9

Gene Name

• GPN3

Ensembl ID

• ENST00000228827
• ENSP00000228827
• ENSG00000111231
• ENST00000537466
• ENSP00000443068
• ENST00000543199
• ENSP00000442770

Symbol

• ATPBD1C
• ATPBD1C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
kinase perturbation	0.84
molecular function	0.81
transcription factor binding site profile	0.8
tissue sample	0.63

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Gpn-loop Gtpase 3

DTO Classes

Protein / Nucleic Acid Binding / Gpn-loop Gtpase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.96   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.96   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (118)

Explore Interacting Targets

1 – 10 of 118

• See Interactions on String-DB

Q6EEV4

Tbio

Family:  Enzyme

Novelty:  0.11413088

p_int:  0.999999963

p_ni:  3.7e-8

Score:  0.594

Data Source:  BioPlex,STRINGDB

POLR3E

Tbio

Family:  Enzyme

Novelty:  0.06500715

p_int:  0.999998952

p_ni:  0.000001048

Score:  0.69

Data Source:  BioPlex,STRINGDB

POLR3D

Tbio

Family:  Enzyme

Novelty:  0.02616321

p_int:  0.999998614

p_ni:  0.000001386

Score:  0.795

Data Source:  BioPlex,STRINGDB

RPAP2

Tbio

Family:  Enzyme

Novelty:  0.03383659

p_int:  0.999983337

p_ni:  0.000016663

Score:  0.947

Data Source:  BioPlex,STRINGDB

POLR2G

Tbio

Family:  Enzyme

Novelty:  0.01235379

p_int:  0.999969909

p_ni:  0.000030091

Score:  0.851

Data Source:  BioPlex,STRINGDB

POLR3H

Tbio

Family:  Enzyme

Novelty:  0.16483597

p_int:  0.999877223

p_ni:  0.000122748

p_wrong:  2.9e-8

Score:  0.815

Data Source:  BioPlex,STRINGDB

POLR2D

Tbio

Family:  Enzyme

Novelty:  0.11021614

p_int:  0.999249167

p_ni:  0.000750833

Score:  0.804

Data Source:  BioPlex,STRINGDB

POLR1E

Tbio

Family:  Enzyme

Novelty:  0.09991103

p_int:  0.999059782

p_ni:  0.00094006

p_wrong:  1.59e-7

Score:  0.253

Data Source:  BioPlex,STRINGDB

POLR3B

Tbio

Family:  Enzyme

Novelty:  0.02526167

p_int:  0.999018637

p_ni:  0.000981363

Score:  0.802

Data Source:  BioPlex,STRINGDB

CD3EAP

Tbio

Family:  Enzyme

Novelty:  0.04978272

p_int:  0.998468867

p_ni:  0.001531121

p_wrong:  1.2e-8

Score:  0.525

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (2)

Components (1)

Find Similar Targets

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1 – 2 of 2

GO Term	Evidence	Assigned by
GTPase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
GTP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	3	2	3		84.1
schizophrenia	MONDO_0005090	1	1	1		54.4
bipolar disorder	EFO_0000289	1	1	1		54.4
body height	EFO_0004339	1	1	1		51.8
QT interval	EFO_0004682	1	1	0	1.2	31.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	3		84.1
schizophrenia	MONDO_0005090	1		54.4
bipolar disorder	EFO_0000289	1		54.4
body height	EFO_0004339	1		51.8
QT interval	EFO_0004682	0	1.2	31.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
GTP-binding
Hydrolase
Nucleotide-binding
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
bipolar disorder
body height
body mass index
QT interval
risk-taking behaviour
schizophrenia

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	GPN-loop GTPase 3	VGNC:5406	452233
Macaque	GPN-loop GTPase 3		709300
Mouse	GPN-loop GTPase 3	MGI:1289326	68080
Rat	GPN-loop GTPase 3	RGD:1303034	360810
Dog	GPN-loop GTPase 3	VGNC:41388	100856764

Species	Name	OMA	EggNOG	Inparanoid
Chimp	GPN-loop GTPase 3
Macaque	GPN-loop GTPase 3
Mouse	GPN-loop GTPase 3
Rat	GPN-loop GTPase 3
Dog	GPN-loop GTPase 3

Publication Statistics

PubMed Score 8.96

PubMed score by year

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PubTator Score 2.50

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (5)

Items per page:

10

0 of 0

PMID	Year	Title