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Tbio
GPN3
GPN-loop GTPase 3

Protein Summary
Description
Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228827
  • ENSP00000228827
  • ENSG00000111231
  • ENST00000537466
  • ENSP00000443068
  • ENST00000543199
  • ENSP00000442770

Symbol
  • ATPBD1C
  • ATPBD1C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
kinase perturbation
0.84
molecular function
0.81
transcription factor binding site profile
0.8
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.96   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.96   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (118)
Q6EEV4
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.999999963
p_ni:  3.7e-8
Score:  0.594
Data Source:  BioPlex,STRINGDB
POLR3E
Tbio
Family:  Enzyme
Novelty:  0.06500715
p_int:  0.999998952
p_ni:  0.000001048
Score:  0.69
Data Source:  BioPlex,STRINGDB
POLR3D
Tbio
Family:  Enzyme
Novelty:  0.02616321
p_int:  0.999998614
p_ni:  0.000001386
Score:  0.795
Data Source:  BioPlex,STRINGDB
RPAP2
Tbio
Family:  Enzyme
Novelty:  0.03383659
p_int:  0.999983337
p_ni:  0.000016663
Score:  0.947
Data Source:  BioPlex,STRINGDB
POLR2G
Tbio
Family:  Enzyme
Novelty:  0.01235379
p_int:  0.999969909
p_ni:  0.000030091
Score:  0.851
Data Source:  BioPlex,STRINGDB
POLR3H
Tbio
Family:  Enzyme
Novelty:  0.16483597
p_int:  0.999877223
p_ni:  0.000122748
p_wrong:  2.9e-8
Score:  0.815
Data Source:  BioPlex,STRINGDB
POLR2D
Tbio
Family:  Enzyme
Novelty:  0.11021614
p_int:  0.999249167
p_ni:  0.000750833
Score:  0.804
Data Source:  BioPlex,STRINGDB
POLR1E
Tbio
Family:  Enzyme
Novelty:  0.09991103
p_int:  0.999059782
p_ni:  0.00094006
p_wrong:  1.59e-7
Score:  0.253
Data Source:  BioPlex,STRINGDB
POLR3B
Tbio
Family:  Enzyme
Novelty:  0.02526167
p_int:  0.999018637
p_ni:  0.000981363
Score:  0.802
Data Source:  BioPlex,STRINGDB
CD3EAP
Tbio
Family:  Enzyme
Novelty:  0.04978272
p_int:  0.998468867
p_ni:  0.001531121
p_wrong:  1.2e-8
Score:  0.525
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
84.1
schizophrenia
1
1
1
54.4
1
1
1
54.4
body height
1
1
1
51.8
QT interval
1
1
0
1.2
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
84.1
schizophrenia
1
54.4
1
54.4
body height
1
51.8
QT interval
0
1.2
31.4
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GPN-loop GTPase 3
VGNC:5406
452233
Macaque
GPN-loop GTPase 3
709300
Mouse
MGI:1289326
68080
Rat
RGD:1303034
360810
Dog
GPN-loop GTPase 3
VGNC:41388
100856764
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GPN-loop GTPase 3
Macaque
GPN-loop GTPase 3
Mouse
Rat
Dog
GPN-loop GTPase 3
Publication Statistics
PubMed Score 8.96
PubMed score by year
PubTator Score 2.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title