Protein Summary
Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
- ENST00000228827
- ENSP00000228827
- ENSG00000111231
- ENST00000537466
- ENSP00000443068
- ENST00000543199
- ENSP00000442770
- ATPBD1C
- ATPBD1C
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.92 | ||
kinase perturbation | 0.84 | ||
molecular function | 0.81 | ||
transcription factor binding site profile | 0.8 | ||
tissue sample | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.71 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 51 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.71 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 51 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (118)
Q6EEV4
Family: Enzyme
Novelty: 0.11413088
p_int: 0.999999963
p_ni: 3.7e-8
Score: 0.594
Data Source: BioPlex,STRINGDB
POLR3E
Family: Enzyme
Novelty: 0.06500715
p_int: 0.999998952
p_ni: 0.000001048
Score: 0.69
Data Source: BioPlex,STRINGDB
POLR3D
Family: Enzyme
Novelty: 0.02616321
p_int: 0.999998614
p_ni: 0.000001386
Score: 0.795
Data Source: BioPlex,STRINGDB
RPAP2
Family: Enzyme
Novelty: 0.03383659
p_int: 0.999983337
p_ni: 0.000016663
Score: 0.947
Data Source: BioPlex,STRINGDB
POLR2G
Family: Enzyme
Novelty: 0.01235379
p_int: 0.999969909
p_ni: 0.000030091
Score: 0.851
Data Source: BioPlex,STRINGDB
POLR3H
Family: Enzyme
Novelty: 0.16483597
p_int: 0.999877223
p_ni: 0.000122748
p_wrong: 2.9e-8
Score: 0.815
Data Source: BioPlex,STRINGDB
POLR2D
Family: Enzyme
Novelty: 0.11021614
p_int: 0.999249167
p_ni: 0.000750833
Score: 0.804
Data Source: BioPlex,STRINGDB
POLR1E
Family: Enzyme
Novelty: 0.09991103
p_int: 0.999059782
p_ni: 0.00094006
p_wrong: 1.59e-7
Score: 0.253
Data Source: BioPlex,STRINGDB
POLR3B
Family: Enzyme
Novelty: 0.02526167
p_int: 0.999018637
p_ni: 0.000981363
Score: 0.802
Data Source: BioPlex,STRINGDB
CD3EAP
Family: Enzyme
Novelty: 0.04978272
p_int: 0.998468867
p_ni: 0.001531121
p_wrong: 1.2e-8
Score: 0.525
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (3)
Functions (2)
Components (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body mass index | 2 | 1 | 2 | 71.3 | |||||
1 | 1 | 1 | 51.7 | ||||||
1 | 1 | 1 | 51.7 | ||||||
body height | 1 | 1 | 1 | 48.5 | |||||
risk-taking behaviour | 1 | 1 | 1 | 21.5 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body mass index | 2 | 71.3 | |||||
1 | 51.7 | ||||||
1 | 51.7 | ||||||
body height | 1 | 48.5 | |||||
risk-taking behaviour | 1 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | GPN-loop GTPase 3 | VGNC:5406 | 452233 | |||||
Macaque | GPN-loop GTPase 3 | 709300 | ||||||
Mouse | MGI:1289326 | 68080 | ||||||
Rat | RGD:1303034 | 360810 | ||||||
Dog | GPN-loop GTPase 3 | VGNC:41388 | 100856764 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | GPN-loop GTPase 3 | |||||
Macaque | GPN-loop GTPase 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | GPN-loop GTPase 3 | |||||
Publication Statistics
PubMed Score 7.71
PubMed score by year
PubTator Score 2.50
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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