You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
GJE1
Putative gap junction epsilon-1 protein

Protein Summary
Description
Mediates calcium-independent ATP release, suggesting activity as a hemichannel. Does not form functional gap junctions.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000450456
  • ENSP00000455469
  • ENSG00000203733

Symbol
  • CX23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.46
ligand (chemical)
0.34
phenotype
0.33
disease
0.28
microRNA
0.24


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.79   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.79   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
GJC1
Tbio
Novelty:  0.00375192
Score:  0.804
Data Source:  STRINGDB
GJA8
Tbio
Novelty:  0.00377739
Score:  0.802
Data Source:  STRINGDB
GJB6
Tbio
Novelty:  0.00119317
Score:  0.747
Data Source:  STRINGDB
GJD3
Tbio
Novelty:  0.05441345
Score:  0.713
Data Source:  STRINGDB
GJA1
Tbio
Novelty:  0.00021332
Score:  0.71
Data Source:  STRINGDB
GJD2
Tbio
Novelty:  0.00263903
Score:  0.698
Data Source:  STRINGDB
GJA4
Tbio
Novelty:  0.0045659
Score:  0.689
Data Source:  STRINGDB
GJB7
Tbio
Novelty:  0.12555147
Score:  0.686
Data Source:  STRINGDB
PANX2
Tbio
Family:  IC
Novelty:  0.00620748
Score:  0.684
Data Source:  STRINGDB
PANX3
Tbio
Family:  IC
Novelty:  0.0071997
Score:  0.673
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
2
2
58.9
1
1
0
1.1
11
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
58.9
0
1.1
11
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1923993
76743
Rat
RGD:1598009
681263
Dog
gap junction protein epsilon 1 [Source:HGNC Symbol;Acc:HGNC:33251]
Horse
gap junction protein epsilon 1 [Source:HGNC Symbol;Acc:HGNC:33251]
Opossum
gap junction epsilon-1 protein-like
100031733
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
gap junction protein epsilon 1 [Source:HGNC Symbol;Acc:HGNC:33251]
Horse
gap junction protein epsilon 1 [Source:HGNC Symbol;Acc:HGNC:33251]
Opossum
gap junction epsilon-1 protein-like
Publication Statistics
PubMed Score 29.79
PubMed score by year
PubTator Score 2.23
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title