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Tdark
FSTL4
Follistatin-related protein 4

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265342
  • ENSP00000265342
  • ENSG00000053108
  • ENST00000621681
  • ENSP00000484273

Symbol
  • KIAA1061
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
trait
0.93
transcription factor binding site profile
0.76
microRNA
0.74
cell type or tissue
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.85   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.85   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
KCMF1
Tbio
Family:  Enzyme
Novelty:  0.05485534
p_int:  0.976065345
p_ni:  0.023934655
Score:  0.815
Data Source:  BioPlex,STRINGDB
UBR4
Tbio
Family:  Enzyme
Novelty:  0.03924839
p_int:  0.958075759
p_ni:  0.041924241
Score:  0.795
Data Source:  BioPlex,STRINGDB
RPL23
Tbio
Novelty:  0.02741113
p_int:  0.879555508
p_ni:  0.120444492
Score:  0.161
Data Source:  BioPlex,STRINGDB
FSTL3
Tbio
Novelty:  0.01238701
Score:  0.67
Data Source:  STRINGDB
GDF15
Tbio
Novelty:  0.00098503
Score:  0.643
Data Source:  STRINGDB
FST
Tbio
Novelty:  0.00085875
Score:  0.622
Data Source:  STRINGDB
DENND5B
Tbio
Novelty:  1.22445822
Score:  0.534
Data Source:  STRINGDB
SPINT3
Tdark
Family:  Enzyme
Novelty:  2.89605083
Score:  0.521
Data Source:  STRINGDB
CHRDL2
Tbio
Novelty:  0.02014764
Score:  0.515
Data Source:  STRINGDB
SH2D4A
Tbio
Novelty:  0.12343277
Score:  0.505
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
4
3
4
84.2
heel bone mineral density
1
1
1
76.3
waist-hip ratio
1
2
2
48.4
high density lipoprotein cholesterol measurement
2
2
2
45.5
alkaline phosphatase measurement
1
1
1
30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
4
84.2
heel bone mineral density
1
76.3
waist-hip ratio
2
48.4
high density lipoprotein cholesterol measurement
2
45.5
alkaline phosphatase measurement
1
30
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
follistatin like 4
VGNC:6877
462061
Macaque
follistatin like 4
709868
Mouse
MGI:2443199
320027
Rat
RGD:1307227
303130
Dog
follistatin like 4
VGNC:41000
481504
Species
Name
OMA
EggNOG
Inparanoid
Chimp
follistatin like 4
Macaque
follistatin like 4
Mouse
Rat
Dog
follistatin like 4
Publication Statistics
PubMed Score 3.85
PubMed score by year
PubTator Score 0.10
PubTator score by year
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Related Publications
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PMID
Year
Title