You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
FAM189A2
Protein FAM189A2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257515
  • ENSP00000257515
  • ENSG00000135063
  • ENST00000455972
  • ENSP00000395675

Symbol
  • C9orf61
  • X123
  • X123
  • C9orf61
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
disease perturbation
0.68
kinase perturbation
0.6
transcription factor
0.6
gene perturbation
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.54   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.54   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
HECW2
Tbio
Family:  Enzyme
Novelty:  0.07194044
p_int:  0.999999223
p_ni:  7.74e-7
p_wrong:  3e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
p_int:  0.99999444
p_ni:  0.00000556
Data Source:  BioPlex
NEDD4
Tchem
Family:  Enzyme
Novelty:  0.00281725
p_int:  0.999969242
p_ni:  0.000030758
Data Source:  BioPlex
WWOX
Tbio
Family:  Enzyme
Novelty:  0.00335243
p_int:  0.999877033
p_ni:  0.000122967
Score:  0.2
Data Source:  BioPlex,STRINGDB
RHBDF2
Tbio
Family:  Enzyme
Novelty:  0.02487334
p_int:  0.999652502
p_ni:  0.00034653
p_wrong:  9.68e-7
Data Source:  BioPlex
ANKRD13D
Tdark
Novelty:  2.14380936
p_int:  0.999567398
p_ni:  0.000432601
p_wrong:  1e-9
Score:  0.167
Data Source:  BioPlex,STRINGDB
ANO6
Tbio
Family:  IC
Novelty:  0.01288434
p_int:  0.999502373
p_ni:  0.000497627
Data Source:  BioPlex
PCNX3
Tdark
Novelty:  0.76597717
p_int:  0.999415175
p_ni:  0.000584825
p_wrong:  1e-9
Data Source:  BioPlex
KCNG1
Tclin
Family:  IC
Novelty:  0.0089612
p_int:  0.999399889
p_ni:  0.000565915
p_wrong:  0.000034196
Score:  0.189
Data Source:  BioPlex,STRINGDB
SLC12A6
Tbio
Family:  Transporter
Novelty:  0.0132619
p_int:  0.99906568
p_ni:  0.000933294
p_wrong:  0.000001027
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
6
6
5
5.9
70.9
self reported educational attainment
3
3
2
6.5
67.1
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
5.9
70.9
self reported educational attainment
2
6.5
67.1
1
50.6
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 189 member A2
VGNC:14385
464516
Macaque
family with sequence similarity 189 member A2
701247
Mouse
MGI:2685813
381217
Rat
RGD:1307524
309415
Dog
family with sequence similarity 189 member A2
VGNC:40638
609015
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 189 member A2
Macaque
family with sequence similarity 189 member A2
Mouse
Rat
Dog
family with sequence similarity 189 member A2
Publication Statistics
PubMed Score 2.54
PubMed score by year
PubTator Score 2.63
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title