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Tdark
FAM168B
Myelin-associated neurite-outgrowth inhibitor

Protein Summary
Description
Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389915
  • ENSP00000374565
  • ENSG00000152102
  • ENST00000409185
  • ENSP00000387051

Symbol
  • KIAA0280L
  • MANI
  • MANI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
histone modification site profile
0.89
cell type or tissue
0.81
microRNA
0.74
cellular component
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.91   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.91   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (19)
SCAF1
Tbio
Novelty:  0.08705338
Score:  0.913
Data Source:  STRINGDB
SRRM1
Tbio
Novelty:  0.03770186
Score:  0.673
Data Source:  STRINGDB
ATP8A2
Tbio
Family:  Transporter
Novelty:  0.03876526
Score:  0.65
Data Source:  STRINGDB
TMEM56
Tdark
Novelty:  0.75633366
Score:  0.621
Data Source:  STRINGDB
RTN4
Tbio
Novelty:  0.00080371
Score:  0.605
Data Source:  STRINGDB
RTN4R
Tbio
Novelty:  0.00196919
Score:  0.603
Data Source:  STRINGDB
AMER3
Tdark
Novelty:  0.42348252
Score:  0.589
Data Source:  STRINGDB
RBM48
Tdark
Novelty:  0.50797247
Score:  0.584
Data Source:  STRINGDB
SEL1L2
Tdark
Novelty:  7.2
Score:  0.574
Data Source:  STRINGDB
GAGE12H
Tdark
Novelty:  10.46750285
Score:  0.559
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 168 member B
VGNC:1945
459610
Mouse
MGI:2448487
214469
Rat
RGD:1583985
690188
Dog
family with sequence similarity 168 member B
VGNC:40620
483857
Cow
family with sequence similarity 168 member B
VGNC:28753
505853
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 168 member B
Mouse
Rat
Dog
family with sequence similarity 168 member B
Cow
family with sequence similarity 168 member B
Publication Statistics
PubMed Score 2.91
PubMed score by year
PubTator Score 67.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title