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Tdark
EQTN
Equatorin

Protein Summary
Description
Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380031
  • ENSP00000369370
  • ENSG00000120160
  • ENST00000380032
  • ENSP00000369371
  • ENST00000537675
  • ENSP00000441630

Symbol
  • AFAF
  • C9orf11
  • AFAF
  • SPACA8
  • C9orf11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.82
kinase perturbation
0.71
cellular component
0.69
tissue
0.46
gene perturbation
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.12   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 21   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.12   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
TEX101
Tbio
Novelty:  0.03488625
Score:  0.738
Data Source:  STRINGDB
CD9
Tbio
Novelty:  0.00095308
Score:  0.663
Data Source:  STRINGDB
ADAM30
Tdark
Family:  Enzyme
Novelty:  0.25395428
Score:  0.657
Data Source:  STRINGDB
ADAM2
Tbio
Family:  Enzyme
Novelty:  0.00586482
Score:  0.655
Data Source:  STRINGDB
P04156
Tchem
Novelty:  0.00033976
Score:  0.647
Data Source:  STRINGDB
F7VJQ1
Tbio
Novelty:  0.00033976
Score:  0.647
Data Source:  STRINGDB
BSG
Tbio
Novelty:  0.0010285
Score:  0.642
Data Source:  STRINGDB
SPATC1
Tdark
Novelty:  0.26477487
Score:  0.609
Data Source:  STRINGDB
CD47
Tchem
Novelty:  0.00129086
Score:  0.599
Data Source:  STRINGDB
HYAL2
Tbio
Family:  Enzyme
Novelty:  0.00740331
Score:  0.592
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
3
3
94.9
hepatocyte growth factor measurement
1
1
1
93.7
endothelial growth factor measurement
1
1
1
93.7
angiopoietin-2 receptor measurement
1
1
1
93.7
angiopoietin-2 measurement
1
1
1
93.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
3
94.9
hepatocyte growth factor measurement
1
93.7
endothelial growth factor measurement
1
93.7
angiopoietin-2 receptor measurement
1
93.7
angiopoietin-2 measurement
1
93.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
equatorin
VGNC:4684
473208
Macaque
equatorin
707334
Mouse
MGI:1915003
67753
Rat
RGD:1563332
500502
Dog
equatorin
VGNC:51714
611648
Species
Name
OMA
EggNOG
Inparanoid
Chimp
equatorin
Macaque
equatorin
Mouse
Rat
Dog
equatorin
Publication Statistics
PubMed Score 28.12
PubMed score by year
PubTator Score 15.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title