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Tbio
EIF4EBP3
Eukaryotic translation initiation factor 4E-binding protein 3

Protein Summary
Description
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310331
  • ENSP00000308472
  • ENSG00000243056

Symbol
  • 4EBP3
  • 4E-BP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
tissue
0.62
histone modification site profile
0.59
transcription factor
0.56
transcription factor binding site profile
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.27   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.27   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
EIF4E2
Tbio
Novelty:  0.0490219
p_int:  0.999927997
p_ni:  0.000072003
Score:  0.573
Data Source:  BioPlex,STRINGDB
EIF4E
Tchem
Novelty:  0.00072182
p_int:  0.99984316
p_ni:  0.00015684
Score:  0.99
Data Source:  BioPlex,STRINGDB
KLHL18
Tdark
Novelty:  0.52915213
p_int:  0.923228064
p_ni:  0.076744154
p_wrong:  0.000027782
Data Source:  BioPlex
EIF4A1
Tchem
Novelty:  0.00269994
Score:  0.954
Data Source:  STRINGDB
EIF4G2
Tbio
Novelty:  0.01424739
Score:  0.905
Data Source:  STRINGDB
EIF4G1
Tbio
Novelty:  0.00170995
Score:  0.903
Data Source:  STRINGDB
EIF4A2
Tbio
Novelty:  0.00298045
Score:  0.872
Data Source:  STRINGDB
EIF4H
Tchem
Novelty:  0.03604365
Score:  0.856
Data Source:  STRINGDB
EIF4B
Tbio
Novelty:  0.00665561
Score:  0.846
Data Source:  STRINGDB
EIF4EBP1
Tbio
Novelty:  0.00098313
Score:  0.809
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
1
0
6.4
42.3
household income
1
1
1
24.5
monocyte count
1
1
1
13.8
inflammatory biomarker measurement
1
1
0
125.7
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
0
6.4
42.3
household income
1
24.5
monocyte count
1
13.8
inflammatory biomarker measurement
0
125.7
6.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4E binding protein 3
VGNC:3975
100533103
Mouse
MGI:1270847
108112
Pig
eukaryotic translation initiation factor 4E binding protein 3
100529254
Platypus
eukaryotic translation initiation factor 4E binding protein 3 [Source:HGNC Symbol;Acc:HGNC:3290]
Zebrafish
ZDB-GENE-030826-26
324490
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4E binding protein 3
Mouse
Pig
eukaryotic translation initiation factor 4E binding protein 3
Platypus
eukaryotic translation initiation factor 4E binding protein 3 [Source:HGNC Symbol;Acc:HGNC:3290]
Zebrafish
Publication Statistics
PubMed Score 7.27
PubMed score by year
PubTator Score 7.19
PubTator score by year
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Related Publications
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PMID
Year
Title