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Tbio
DUS4L
tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like

Protein Summary
Description
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265720
  • ENSP00000265720
  • ENSG00000105865
  • ENST00000639937
  • ENSP00000491438
  • ENSG00000284103

Symbol
  • DUS4
  • PP35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
cell type or tissue
0.68
transcription factor binding site profile
0.6
molecular function
0.56
transcription factor
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.21   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.21   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
PTPRG
Tchem
Family:  Enzyme
Novelty:  0.01920574
p_int:  0.990977078
p_ni:  0.009022922
Score:  0.157
Data Source:  BioPlex,STRINGDB
ULBP2
Tbio
Novelty:  0.01604318
p_int:  0.94878723
p_ni:  0.051175758
p_wrong:  0.000037012
Score:  0.22
Data Source:  BioPlex,STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
p_int:  0.911886698
p_ni:  0.08810187
p_wrong:  0.000011431
Score:  0.194
Data Source:  BioPlex,STRINGDB
TOP1
Tclin
Family:  Enzyme
Novelty:  0.00019573
p_int:  0.860040648
p_ni:  0.139959352
Score:  0.209
Data Source:  BioPlex,STRINGDB
GCA
Tbio
Novelty:  0.01485875
p_int:  0.791342539
p_ni:  0.154801901
p_wrong:  0.053855561
Score:  0.241
Data Source:  BioPlex,STRINGDB
BCAP29
Tbio
Novelty:  0.09095623
Score:  0.925
Data Source:  STRINGDB
COG5
Tbio
Novelty:  0.04017657
Score:  0.876
Data Source:  STRINGDB
GPR22
Tbio
Family:  GPCR
Novelty:  0.1822753
Score:  0.808
Data Source:  STRINGDB
TRMT61A
Tbio
Family:  Enzyme
Novelty:  0.04443394
Score:  0.758
Data Source:  STRINGDB
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
Score:  0.75
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
9.2
85.1
alkaline phosphatase measurement
2
2
1
9.2
85.1
5
5
3
1.1
80.6
5
5
3
1.1
80.6
vitamin D measurement
2
1
2
63.6
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
9.2
85.1
alkaline phosphatase measurement
1
9.2
85.1
3
1.1
80.6
3
1.1
80.6
vitamin D measurement
2
63.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dihydrouridine synthase 4 like
VGNC:7377
463652
Mouse
MGI:1919166
71916
Rat
RGD:1311445
366593
Dog
dihydrouridine synthase 4 like
VGNC:40125
483264
Horse
dihydrouridine synthase 4 like
VGNC:17345
100050690
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dihydrouridine synthase 4 like
Mouse
Rat
Dog
dihydrouridine synthase 4 like
Horse
dihydrouridine synthase 4 like
Publication Statistics
PubMed Score 66.21
PubMed score by year
PubTator Score 7.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title