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Tbio
DNASE2B
Deoxyribonuclease-2-beta

Protein Summary
Description
Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation. The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370662
  • ENSP00000359696
  • ENSG00000137976
  • ENST00000370665
  • ENSP00000359699

Symbol
  • DLAD
  • DLAD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
transcription factor
0.59
virus perturbation
0.55
gene perturbation
0.52
cellular component
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.27   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.27   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
SUCO
Tdark
Novelty:  0.00074481
p_int:  0.999996059
p_ni:  0.000003941
Score:  0.189
Data Source:  BioPlex,STRINGDB
FUT11
Tbio
Family:  Enzyme
Novelty:  0.16098097
p_int:  0.998669658
p_ni:  0.001330217
p_wrong:  1.25e-7
Data Source:  BioPlex
GALNS
Tbio
Family:  Enzyme
Novelty:  0.00510529
p_int:  0.99828253
p_ni:  0.00171747
Data Source:  BioPlex
WIPI1
Tbio
Novelty:  0.01070744
p_int:  0.992436366
p_ni:  0.000025632
p_wrong:  0.007538002
Score:  0.189
Data Source:  BioPlex,STRINGDB
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.968745128
p_ni:  0.031254872
Data Source:  BioPlex
PPP2R5E
Tbio
Family:  Enzyme
Novelty:  0.05974697
p_int:  0.96626954
p_ni:  0.033451704
p_wrong:  0.000278756
Data Source:  BioPlex
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.964646016
p_ni:  0.035353984
Data Source:  BioPlex
TMEM132A
Tdark
Novelty:  0.26489093
p_int:  0.93707525
p_ni:  0.06292475
Data Source:  BioPlex
TRAPPC2
Tbio
Novelty:  0.02016231
p_int:  0.93402737
p_ni:  0.065965861
p_wrong:  0.000006769
Data Source:  BioPlex
PPP2R5D
Tbio
Family:  Enzyme
Novelty:  0.03990599
p_int:  0.922724216
p_ni:  0.077250423
p_wrong:  0.000025361
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deoxyribonuclease 2 beta
VGNC:1230
469369
Macaque
deoxyribonuclease 2 beta
710197
Mouse
MGI:1913283
56629
Rat
RGD:70901
59296
Dog
deoxyribonuclease 2 beta
VGNC:40027
479973
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deoxyribonuclease 2 beta
Macaque
deoxyribonuclease 2 beta
Mouse
Rat
Dog
deoxyribonuclease 2 beta
Publication Statistics
PubMed Score 41.27
PubMed score by year
PubTator Score 10.83
PubTator score by year
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Related Publications
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PMID
Year
Title