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Tbio
DLEC1
Deleted in lung and esophageal cancer protein 1

Protein Summary
Description
May act as a tumor suppressor by inhibiting cell proliferation. The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308059
  • ENSP00000308597
  • ENSG00000008226
  • ENST00000346219
  • ENSP00000315914

Symbol
  • DLC1
  • F56
  • DLC1
  • DLC-1
  • CFAP81
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
cell line
0.58
cell type or tissue
0.56
tissue sample
0.5
histone modification site profile
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.47   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.47   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
SLC52A3
Tbio
Family:  Transporter
Novelty:  0.01271599
Score:  0.72
Data Source:  STRINGDB
RNF6
Tbio
Family:  Enzyme
Novelty:  0.06214038
Score:  0.713
Data Source:  STRINGDB
S100A14
Tbio
Novelty:  0.03462448
Score:  0.711
Data Source:  STRINGDB
LZTS1
Tbio
Novelty:  0.02747372
Score:  0.71
Data Source:  STRINGDB
RASSF1
Tbio
Novelty:  0.00137149
Score:  0.654
Data Source:  STRINGDB
PLCE1
Tbio
Family:  Enzyme
Novelty:  0.0070258
Score:  0.627
Data Source:  STRINGDB
CFAP47
Tdark
Novelty:  0.59170159
Score:  0.614
Data Source:  STRINGDB
CFAP65
Tdark
Novelty:  0.20563218
Score:  0.605
Data Source:  STRINGDB
PLCD1
Tchem
Family:  Enzyme
Novelty:  0.00742197
Score:  0.602
Data Source:  STRINGDB
OXSR1
Tbio
Family:  Kinase
Novelty:  0.11142923
Score:  0.572
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
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1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
1
2
80.2
hemoglobin measurement
2
1
2
80.2
mean reticulocyte volume
1
1
1
75.6
mean corpuscular volume
1
1
1
72.6
monocyte count
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
80.2
hemoglobin measurement
2
80.2
mean reticulocyte volume
1
75.6
mean corpuscular volume
1
72.6
monocyte count
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deleted in lung and esophageal cancer 1
470790
Macaque
deleted in lung and esophageal cancer 1
697163
Mouse
MGI:2443671
320256
Dog
DLEC1, cilia and flagella associated protein
VGNC:54779
100686697
Horse
DLEC1, cilia and flagella associated protein
VGNC:54775
100054035
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deleted in lung and esophageal cancer 1
Macaque
deleted in lung and esophageal cancer 1
Mouse
Dog
DLEC1, cilia and flagella associated protein
Horse
DLEC1, cilia and flagella associated protein
Publication Statistics
PubMed Score 40.47
PubMed score by year
PubTator Score 41.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title