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Tbio
CREM
cAMP-responsive element modulator

Protein Summary
Description
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found fo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337656
  • ENSP00000337138
  • ENSG00000095794
  • ENST00000342105
  • ENSP00000341875
  • ENST00000345491
  • ENSP00000265372
  • ENST00000348787
  • ENSP00000345384
  • ENST00000354759
  • ENSP00000346804
  • ENST00000356917
  • ENSP00000349387
  • ENST00000361599
  • ENSP00000354593
  • ENST00000374726
  • ENSP00000363858
  • ENST00000374728
  • ENSP00000363860
  • ENST00000374734
  • ENSP00000363866
  • ENST00000395887
  • ENSP00000379225
  • ENST00000429130
  • ENSP00000393538
  • ENST00000439705
  • ENSP00000409220
  • ENST00000463314
  • ENSP00000418336
  • ENST00000468236
  • ENSP00000419810
  • ENST00000473940
  • ENSP00000420681
  • ENST00000474931
  • ENSP00000417562
  • ENST00000479070
  • ENSP00000420511
  • ENST00000487763
  • ENSP00000417807
  • ENST00000488328
  • ENSP00000417460
  • ENST00000488741
  • ENSP00000419075
  • ENST00000489321
  • ENSP00000419924
  • ENST00000490511
  • ENSP00000417327

Symbol
  • ICER
  • CREM-2
  • hCREM-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase
0.98
transcription factor
0.95
kinase perturbation
0.93
disease perturbation
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2758.55   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 391   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2758.55   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 391   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0