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Tdark
CCDC107
Coiled-coil domain-containing protein 107

Protein Summary
Description
This gene encodes a membrane protein which contains a coiled-coil domain in the central region. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327351
  • ENSP00000330327
  • ENSG00000159884
  • ENST00000378407
  • ENSP00000367662
  • ENST00000378409
  • ENSP00000367665
  • ENST00000421582
  • ENSP00000413003
  • ENST00000426546
  • ENSP00000414964

Symbol
  • PSEC0222
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
tissue sample
0.64
histone modification site profile
0.63
transcription factor binding site profile
0.58
cell line
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.1   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.1   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
TRPM4
Tchem
Family:  IC
Novelty:  0.00423106
p_int:  0.999962439
p_ni:  0.000035795
p_wrong:  0.000001766
Score:  0.158
Data Source:  BioPlex,STRINGDB
GCC2
Tbio
Novelty:  0.03809539
p_int:  0.99992694
p_ni:  0.00007306
Data Source:  BioPlex
STX18
Tbio
Novelty:  0.0259034
p_int:  0.999669345
p_ni:  0.000330655
Score:  0.224
Data Source:  BioPlex,STRINGDB
BNIP1
Tbio
Novelty:  0.04601895
p_int:  0.999246529
p_ni:  0.000753471
Score:  0.186
Data Source:  BioPlex,STRINGDB
FBXO11
Tbio
Novelty:  0.02762674
p_int:  0.998717589
p_ni:  0.001282411
Data Source:  BioPlex
SLC9A1
Tchem
Family:  Transporter
Novelty:  0.00096678
p_int:  0.988645345
p_ni:  0.011348838
p_wrong:  0.000005817
Data Source:  BioPlex
TMEM214
Tdark
Novelty:  0.32604613
p_int:  0.988191134
p_ni:  0.011808866
Data Source:  BioPlex
GOLGA5
Tbio
Novelty:  0.04940885
p_int:  0.979005228
p_ni:  0.020994772
Data Source:  BioPlex
CENPH
Tbio
Novelty:  0.02845079
p_int:  0.974117646
p_ni:  0.025882354
Data Source:  BioPlex
ALG8
Tbio
Family:  Enzyme
Novelty:  0.03721075
p_int:  0.969961374
p_ni:  0.027483696
p_wrong:  0.002554929
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
74.8
lymphocyte count
2
1
2
74.4
leukocyte count
1
1
1
68.6
red blood cell distribution width
1
1
1
64
body height
1
1
1
62.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
74.8
lymphocyte count
2
74.4
leukocyte count
1
68.6
red blood cell distribution width
1
64
body height
1
62.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 107
VGNC:4647
465076
Macaque
coiled-coil domain containing 107
696972
Mouse
MGI:1913423
622404
Rat
RGD:1560252
313496
Dog
coiled-coil domain containing 107
VGNC:38779
611925
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 107
Macaque
coiled-coil domain containing 107
Mouse
Rat
Dog
coiled-coil domain containing 107
Publication Statistics
PubMed Score 2.10
PubMed score by year
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Related Publications
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PMID
Year
Title