Tdark CCDC106 Coiled-coil domain-containing protein 106

Protein Summary

Description

Promotes the degradation of p53/TP53 protein and inhibits its transactivity.

Uniprot Accession IDs

• Q9BWC9
• B3KUF9
• D3K183
• Q99786

Gene Name

• CCDC106

Ensembl ID

• ENST00000308964
• ENSP00000309681
• ENSG00000173581
• ENST00000586790
• ENSP00000465757
• ENST00000588740
• ENSP00000468539
• ENST00000591578
• ENSP00000466870

Symbol

• ZNF581
• HSU79303

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.82
transcription factor	0.64
cellular component	0.63
small molecule perturbation	0.61
kinase perturbation	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.02   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 184   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.02   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (21)

Explore Interacting Targets

1 – 10 of 21

• See Interactions on String-DB

CEBPG

Tbio

Family:  TF

Novelty:  0.07956633

p_int:  0.99997769

p_ni:  0.000022306

p_wrong:  4e-9

Data Source:  BioPlex

TERF2

Tchem

Family:  TF

Novelty:  0.01003649

p_int:  0.999200797

p_ni:  0.000799195

p_wrong:  8e-9

Score:  0.234

Data Source:  BioPlex,STRINGDB

TERF2IP

Tchem

Novelty:  0.06285957

p_int:  0.998545152

p_ni:  0.001454848

Score:  0.232

Data Source:  BioPlex,STRINGDB

CAMK1

Tchem

Family:  Kinase

Novelty:  0.01239891

p_int:  0.998385169

p_ni:  0.001614831

Score:  0.258

Data Source:  BioPlex,STRINGDB

CSNK2B

Tbio

Family:  Kinase

Novelty:  0.00152367

p_int:  0.998359447

p_ni:  0.001503287

p_wrong:  0.000137266

Data Source:  BioPlex

MAGEA10

Tbio

Novelty:  0.05364393

p_int:  0.995768222

p_ni:  0.004231745

p_wrong:  3.3e-8

Score:  0.177

Data Source:  BioPlex,STRINGDB

NEFM

Tbio

Novelty:  0.00239134

p_int:  0.985529744

p_ni:  0.014470256

Score:  0.324

Data Source:  BioPlex,STRINGDB

TP53

Tchem

Family:  TF

Novelty:  0.00001907

Score:  0.917

Data Source:  STRINGDB

HABP4

Tbio

Novelty:  0.10672749

Score:  0.632

Data Source:  STRINGDB

SNX15

Tdark

Novelty:  0.27466573

Score:  0.63

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (2)

Components (2)

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1 – 2 of 2

GO Term	Evidence	Assigned by
cytosol	Inferred from Direct Assay (IDA)	HPA
nucleus	Inferred from Direct Assay (IDA)	HPA

Disease Associations (null)

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	3	2	3		72.7
insomnia measurement	EFO_0007876	1	2	0	1.1	56.3
high density lipoprotein cholesterol measurement	EFO_0004612	1	1	1		21.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	3		72.7
insomnia measurement	EFO_0007876	0	1.1	56.3
high density lipoprotein cholesterol measurement	EFO_0004612	1		21.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Coiled coil
Complete proteome
Nucleus
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
high density lipoprotein cholesterol measurement
insomnia measurement
triglyceride measurement

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	coiled-coil domain containing 106	VGNC:3645	737195
Macaque	coiled-coil domain containing 106		702611
Mouse	coiled-coil domain containing 106	MGI:2385900	232821
Rat	coiled-coil domain containing 106	RGD:1566222	499071
Dog	coiled-coil domain containing 106	VGNC:38778	476376

Species	Name	OMA	EggNOG	Inparanoid
Chimp	coiled-coil domain containing 106
Macaque	coiled-coil domain containing 106
Mouse	coiled-coil domain containing 106
Rat	coiled-coil domain containing 106
Dog	coiled-coil domain containing 106

Publication Statistics

PubMed Score 3.02

PubMed score by year

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PubTator Score 0.67

PubTator score by year

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Related Publications

Text Mined References (11)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title