Tdark CCDC106 Coiled-coil domain-containing protein 106

Protein Summary

Description

Promotes the degradation of p53/TP53 protein and inhibits its transactivity.

Uniprot Accession IDs

• Q9BWC9
• B3KUF9
• D3K183
• Q99786

Gene Name

• CCDC106

Ensembl ID

• ENST00000308964
• ENSP00000309681
• ENSG00000173581
• ENST00000586790
• ENSP00000465757
• ENST00000588740
• ENSP00000468539
• ENST00000591578
• ENSP00000466870

Symbol

• ZNF581
• HSU79303

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.82
transcription factor	0.64
cellular component	0.63
small molecule perturbation	0.61
kinase perturbation	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.33   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 184   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.33   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0