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Tdark
CCDC106
Coiled-coil domain-containing protein 106

Protein Summary
Description
Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308964
  • ENSP00000309681
  • ENSG00000173581
  • ENST00000586790
  • ENSP00000465757
  • ENST00000588740
  • ENSP00000468539
  • ENST00000591578
  • ENSP00000466870

Symbol
  • ZNF581
  • HSU79303
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
transcription factor
0.64
cellular component
0.63
small molecule perturbation
0.61
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.02   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.02   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
CEBPG
Tbio
Family:  TF
Novelty:  0.07956633
p_int:  0.99997769
p_ni:  0.000022306
p_wrong:  4e-9
Data Source:  BioPlex
TERF2
Tchem
Family:  TF
Novelty:  0.01003649
p_int:  0.999200797
p_ni:  0.000799195
p_wrong:  8e-9
Score:  0.234
Data Source:  BioPlex,STRINGDB
TERF2IP
Tchem
Novelty:  0.06285957
p_int:  0.998545152
p_ni:  0.001454848
Score:  0.232
Data Source:  BioPlex,STRINGDB
CAMK1
Tchem
Family:  Kinase
Novelty:  0.01239891
p_int:  0.998385169
p_ni:  0.001614831
Score:  0.258
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.998359447
p_ni:  0.001503287
p_wrong:  0.000137266
Data Source:  BioPlex
MAGEA10
Tbio
Novelty:  0.05364393
p_int:  0.995768222
p_ni:  0.004231745
p_wrong:  3.3e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
NEFM
Tbio
Novelty:  0.00239134
p_int:  0.985529744
p_ni:  0.014470256
Score:  0.324
Data Source:  BioPlex,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.917
Data Source:  STRINGDB
HABP4
Tbio
Novelty:  0.10672749
Score:  0.632
Data Source:  STRINGDB
SNX15
Tdark
Novelty:  0.27466573
Score:  0.63
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
2
3
72.7
insomnia measurement
1
2
0
1.1
56.3
high density lipoprotein cholesterol measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
72.7
insomnia measurement
0
1.1
56.3
high density lipoprotein cholesterol measurement
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 106
VGNC:3645
737195
Macaque
coiled-coil domain containing 106
702611
Mouse
MGI:2385900
232821
Rat
RGD:1566222
499071
Dog
coiled-coil domain containing 106
VGNC:38778
476376
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 106
Macaque
coiled-coil domain containing 106
Mouse
Rat
Dog
coiled-coil domain containing 106
Publication Statistics
PubMed Score 3.02
PubMed score by year
PubTator Score 0.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title