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Tbio
CARD19
Caspase recruitment domain-containing protein 19

Protein Summary
Description
Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375464
  • ENSP00000364613
  • ENSG00000165233
  • ENST00000466409
  • ENSP00000437237

Symbol
  • C9orf89
  • BinCARD
  • C9orf89
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.24   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.24   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (14)
TRAK1
Tbio
Novelty:  0.03561577
p_int:  0.99999997
p_ni:  3e-8
Data Source:  BioPlex
TRAK2
Tbio
Novelty:  0.04192075
p_int:  0.999998874
p_ni:  4.85e-7
p_wrong:  6.41e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
CD244
Tbio
Novelty:  0.01137579
p_int:  0.999997983
p_ni:  0.000002006
p_wrong:  1.1e-8
Score:  0.635
Data Source:  BioPlex,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.999979792
p_ni:  0.000017819
p_wrong:  0.000002388
Data Source:  BioPlex
MTX2
Tbio
Novelty:  0.02047483
p_int:  0.999941459
p_ni:  0.00000988
p_wrong:  0.000048662
Score:  0.817
Data Source:  BioPlex,STRINGDB
EXOC6
Tbio
Novelty:  0.01886811
p_int:  0.999802788
p_ni:  0.000195363
p_wrong:  0.00000185
Score:  0.173
Data Source:  BioPlex,STRINGDB
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.998337492
p_ni:  0.0011895
p_wrong:  0.000473008
Data Source:  BioPlex
CRACR2B
Tbio
Novelty:  1.05982042
p_int:  0.997881111
p_ni:  0.000169173
p_wrong:  0.001949716
Score:  0.455
Data Source:  BioPlex,STRINGDB
FAM3B
Tbio
Novelty:  0.00844967
p_int:  0.974455831
p_ni:  0.002152084
p_wrong:  0.023392086
Score:  0.23
Data Source:  BioPlex,STRINGDB
BCL10
Tbio
Novelty:  0.00253704
Score:  0.77
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
2
2
1
9.8
77.6
serum alanine aminotransferase measurement
2
1
1
8.6
69
L lactate dehydrogenase measurement
1
1
1
62.1
mean platelet volume
1
1
1
50.6
platelet crit
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
9.8
77.6
serum alanine aminotransferase measurement
1
8.6
69
L lactate dehydrogenase measurement
1
62.1
mean platelet volume
1
50.6
platelet crit
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915730
68480
Rat
RGD:1306058
361224
Dog
caspase recruitment domain family member 19
VGNC:38716
100856030
Horse
caspase recruitment domain family member 19 [Source:HGNC Symbol;Acc:HGNC:28148]
Cow
caspase recruitment domain family member 19
614217
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
caspase recruitment domain family member 19
Horse
caspase recruitment domain family member 19 [Source:HGNC Symbol;Acc:HGNC:28148]
Cow
caspase recruitment domain family member 19
Publication Statistics
PubMed Score 6.24
PubMed score by year
PubTator Score 1.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title