Tdark B4GALNT4 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1

Protein Summary

Description

Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.

Uniprot Accession IDs

• Q76KP1
• Q96LV2
• NGalNAc-T1

Gene Name

• B4GALNT4

Ensembl ID

• ENST00000329962
• ENSP00000328277
• ENSG00000182272

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.65
transcription factor	0.59
cellular component	0.58
PubMedID	0.58
histone modification site profile	0.5

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-n-acetylgalactosaminyltransferase 1

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-n-acetylgalactosaminyltransferase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.99   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 4   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.99   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (48)

Explore Interacting Targets

1 – 10 of 48

• See Interactions on String-DB

PILRA

Tbio

Novelty:  0.05154386

p_int:  0.999999262

p_ni:  7.37e-7

p_wrong:  1e-9

Score:  0.52

Data Source:  BioPlex,STRINGDB

CSN1S1

Tbio

Family:  Enzyme

Novelty:  0.00200522

p_int:  0.998772617

p_ni:  0.000704747

p_wrong:  0.000522636

Score:  0.187

Data Source:  BioPlex,STRINGDB

LYZL2

Tdark

Family:  Enzyme

Novelty:  0.50542161

p_int:  0.998772617

p_ni:  0.000704747

p_wrong:  0.000522636

Data Source:  BioPlex

ANTXR1

Tbio

Novelty:  0.00508081

p_int:  0.963665579

p_ni:  0.00004201

p_wrong:  0.036292412

Score:  0.218

Data Source:  BioPlex,STRINGDB

INSL5

Tbio

Novelty:  0.04351334

p_int:  0.95805752

p_ni:  0.000057456

p_wrong:  0.041885025

Data Source:  BioPlex

INS

Tbio

Novelty:  0.00000499

p_int:  0.878011165

p_ni:  0.000542852

p_wrong:  0.121445982

Data Source:  BioPlex

PGGHG

Tbio

Family:  Enzyme

Novelty:  0.40196205

Score:  0.858

Data Source:  STRINGDB

B4GALNT3

Tbio

Family:  Enzyme

Novelty:  0.1822928

Score:  0.815

Data Source:  STRINGDB

C1QTNF4

Tbio

Novelty:  0.10701626

Score:  0.756

Data Source:  STRINGDB

MXRA7

Tdark

Novelty:  0.20850504

Score:  0.673

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

KEGG (2)

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1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Various types of N-glycan biosynthesis	39 targets	path:hsa00513
KEGG	Metabolic pathways	1433 targets	path:hsa01100

Name	Explore in Pharos	Explore in Source
Various types of N-glycan biosynthesis	39 targets	path:hsa00513
Metabolic pathways	1433 targets	path:hsa01100

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (2)

Components (2)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
acetylgalactosaminyltransferase activity	Inferred from Direct Assay (IDA)	HGNC
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations (null)

No disease associations found

GWAS Traits (32)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 32

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	3	3	3	17.9	96.7
eosinophil count	EFO_0004842	3	3	4		96.7
eosinophil percentage of leukocytes	EFO_0007991	2	4	4		96.5
monocyte percentage of leukocytes	EFO_0007989	2	3	4		96.2
leukocyte count	EFO_0004308	2	3	3		96.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 32

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	3	17.9	96.7
eosinophil count	EFO_0004842	4		96.7
eosinophil percentage of leukocytes	EFO_0007991	4		96.5
monocyte percentage of leukocytes	EFO_0007989	4		96.2
leukocyte count	EFO_0004308	3		96.2

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UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Glycoprotein
Golgi apparatus
Membrane
Polymorphism
Reference proteome
Signal-anchor
Transferase
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
apolipoprotein A 1 measurement
autoimmune thyroid disease
basophil count
creatinine measurement
eosinophil count
eosinophil percentage of granulocytes
eosinophil percentage of leukocytes
granulocyte count
granulocyte percentage of myeloid white cells

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	beta-1,4-N-acetyl-galactosaminyltransferase 4	VGNC:7796	450920
Macaque	beta-1,4-N-acetyl-galactosaminyltransferase 4		720768
Mouse	beta-1,4-N-acetyl-galactosaminyl transferase 4	MGI:2652891	330671
Rat	beta-1,4-N-acetyl-galactosaminyl transferase 4	RGD:1310052	309105
Dog	beta-1,4-N-acetyl-galactosaminyltransferase 4	VGNC:38348	483398

Species	Name	OMA	EggNOG	Inparanoid
Chimp	beta-1,4-N-acetyl-galactosaminyltransferase 4
Macaque	beta-1,4-N-acetyl-galactosaminyltransferase 4
Mouse	beta-1,4-N-acetyl-galactosaminyl transferase 4
Rat	beta-1,4-N-acetyl-galactosaminyl transferase 4
Dog	beta-1,4-N-acetyl-galactosaminyltransferase 4

Publication Statistics

PubMed Score 4.99

PubMed score by year

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PubTator Score 1.75

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (6)

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PMID	Year	Title